Wikipedia gpewiki https://gpe.wikipedia.org/wiki/Main_Page MediaWiki 1.47.0-wmf.2 first-letter Media Special Talk User User talk Wikipedia Wikipedia talk File File talk MediaWiki MediaWiki talk Template Template talk Help Help talk Category Category talk TimedText TimedText talk Module Module talk Event Event talk 0 26867 98083 98082 2026-05-14T17:39:56Z DaSupremo 9 Improve article 98083 wikitext text/x-wiki {{Databox}} '''Progressive supranuclear palsy''' ('''PSP''') be a non late-onset neurodegenerative disease wey dey involve de gradual deterioration den death of specific volumes of de brain, dem link to 4-repeat tau pathology.<ref name="Golbe20142">{{cite journal |vauthors=Golbe LI |date=April 2014 |title=Progressive supranuclear palsy |journal=Seminars in Neurology |volume=34 |issue=2 |pages=151–9 |doi=10.1055/s-0034-1381736 |pmid=24963674 |doi-access=free}}</ref><ref name="ICD112">{{cite web |title=ICD-11 - Mortality and Morbidity Statistics |url=https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1493396558 |website=icd.who.int}}</ref><ref name=":0">{{Cite journal |last1=Boxer |first1=Adam L |last2=Yu |first2=Jin-Tai |last3=Golbe |first3=Lawrence I |last4=Litvan |first4=Irene |last5=Lang |first5=Anthony E |last6=Höglinger |first6=Günter U |date=July 2017 |title=Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches |journal=The Lancet Neurology |language=en |volume=16 |issue=7 |pages=552–563 |doi=10.1016/S1474-4422(17)30157-6|pmid=28653647 |pmc=5802400 }}</ref> De condition dey lead to symptoms wey dey include loss of balance, slowing of movement, difficulty dey move de eyes, den cognitive impairment.<ref name="Golbe20142" /> PSP fi be mistaken for oda types of neurodegeneration such as [[Parkinson's disease]], [[frontotemporal dementia]] den Alzheimer's disease. E be de second most common tauopathy behind [[Alzheimer's disease]]. De cause of de condition be uncertain, buh dey involve de accumulation of tau protein within de brain. Medications such as levodopa den amantadine fi be useful insyd sam cases.<ref name="Golbe20142" /> Na dem first describe PSP by Richardson, Steele, den Olszewski insyd 1963 as a form of progressive parkinsonism.<ref name=":3">{{Cite journal |last1=Lopez |first1=G. |last2=Bayulkem |first2=K. |last3=Hallett |first3=M. |date=October 2016 |title=Progressive supranuclear palsy (PSP): Richardson syndrome and other PSP variants |journal=Acta Neurologica Scandinavica |language=en |volume=134 |issue=4 |pages=242–249 |doi=10.1111/ane.12546|pmid=27070344 |pmc=7292631 }}</ref> However, de earliest known case wey dey present clinical dey feature consistent plus PSP, along plus pathological confirmation, na dem report insyd [[France]] insyd 1951.<ref name=":13">{{Cite journal |last1=Brusa |first1=Adolfo |last2=Stoehr |first2=Rolf |last3=Pramstaller |first3=Peter P. |date=March 2004 |title=Progressive supranuclear palsy: New disease or variant of postencephalitic parkinsonism? |url=https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.10699 |journal=Movement Disorders |language=en |volume=19 |issue=3 |pages=247–252 |doi=10.1002/mds.10699 |pmid=15022178 |issn=0885-3185}}</ref> Originally dem think am to be a more general type of atypical parkinsonism, PSP be linked to distinct clinical phenotypes wey dey include '''PSP-Richardson's syndrome (PSP-RS)''', wich be de most common sub-type of de disease.<ref name=":6">{{Cite journal |last1=Coughlin |first1=David G. |last2=Litvan |first2=Irene |date=April 2020 |title=Progressive supranuclear palsy: Advances in diagnosis and management |journal=Parkinsonism & Related Disorders |language=en |volume=73 |pages=105–116 |doi=10.1016/j.parkreldis.2020.04.014|pmid=32487421 |pmc=7462164 }}</ref> As PSP dey advance to a fully symptomatic stage, chaw PSP subtypes eventually dey exhibit de clinical characteristics of PSP-RS.<ref name=":0" /> == References == [[Category:Translated from MDWiki]] <references /> == External links == drpbm2il8xetydx08h46iwhkeujwtwr 98084 98083 2026-05-14T17:42:32Z DaSupremo 9 Improve article 98084 wikitext text/x-wiki {{Databox}} '''Progressive supranuclear palsy''' ('''PSP''') be a non late-onset neurodegenerative disease wey dey involve de gradual deterioration den death of specific volumes of de brain, dem link to 4-repeat tau pathology.<ref name="Golbe20142">{{cite journal |vauthors=Golbe LI |date=April 2014 |title=Progressive supranuclear palsy |journal=Seminars in Neurology |volume=34 |issue=2 |pages=151–9 |doi=10.1055/s-0034-1381736 |pmid=24963674 |doi-access=free}}</ref><ref name="ICD112">{{cite web |title=ICD-11 - Mortality and Morbidity Statistics |url=https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1493396558 |website=icd.who.int}}</ref><ref name=":0">{{Cite journal |last1=Boxer |first1=Adam L |last2=Yu |first2=Jin-Tai |last3=Golbe |first3=Lawrence I |last4=Litvan |first4=Irene |last5=Lang |first5=Anthony E |last6=Höglinger |first6=Günter U |date=July 2017 |title=Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches |journal=The Lancet Neurology |language=en |volume=16 |issue=7 |pages=552–563 |doi=10.1016/S1474-4422(17)30157-6|pmid=28653647 |pmc=5802400 }}</ref> De condition dey lead to symptoms wey dey include loss of balance, slowing of movement, difficulty dey move de eyes, den cognitive impairment.<ref name="Golbe20142" /> PSP fi be mistaken for oda types of neurodegeneration such as [[Parkinson's disease]], [[frontotemporal dementia]] den Alzheimer's disease. E be de second most common tauopathy behind [[Alzheimer's disease]]. De cause of de condition be uncertain, buh dey involve de accumulation of tau protein within de brain. Medications such as levodopa den amantadine fi be useful insyd sam cases.<ref name="Golbe20142" /> Na dem first describe PSP by Richardson, Steele, den Olszewski insyd 1963 as a form of progressive parkinsonism.<ref name=":3">{{Cite journal |last1=Lopez |first1=G. |last2=Bayulkem |first2=K. |last3=Hallett |first3=M. |date=October 2016 |title=Progressive supranuclear palsy (PSP): Richardson syndrome and other PSP variants |journal=Acta Neurologica Scandinavica |language=en |volume=134 |issue=4 |pages=242–249 |doi=10.1111/ane.12546|pmid=27070344 |pmc=7292631 }}</ref> However, de earliest known case wey dey present clinical dey feature consistent plus PSP, along plus pathological confirmation, na dem report insyd [[France]] insyd 1951.<ref name=":13">{{Cite journal |last1=Brusa |first1=Adolfo |last2=Stoehr |first2=Rolf |last3=Pramstaller |first3=Peter P. |date=March 2004 |title=Progressive supranuclear palsy: New disease or variant of postencephalitic parkinsonism? |url=https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.10699 |journal=Movement Disorders |language=en |volume=19 |issue=3 |pages=247–252 |doi=10.1002/mds.10699 |pmid=15022178 |issn=0885-3185}}</ref> Originally dem think am to be a more general type of atypical parkinsonism, PSP be linked to distinct clinical phenotypes wey dey include '''PSP-Richardson's syndrome (PSP-RS)''', wich be de most common sub-type of de disease.<ref name=":6">{{Cite journal |last1=Coughlin |first1=David G. |last2=Litvan |first2=Irene |date=April 2020 |title=Progressive supranuclear palsy: Advances in diagnosis and management |journal=Parkinsonism & Related Disorders |language=en |volume=73 |pages=105–116 |doi=10.1016/j.parkreldis.2020.04.014|pmid=32487421 |pmc=7462164 }}</ref> As PSP dey advance to a fully symptomatic stage, chaw PSP subtypes eventually dey exhibit de clinical characteristics of PSP-RS.<ref name=":0" /> PSP of all phenotypes get a prevalence of 18 per 100,000, whereas PSP-RS dey affect approximately 5 to 7 per 100,000 individuals.<ref name="Golbe20142" /><ref name=":0" /> De first symptoms typically dey occur at 60–70 years of age. Males slightly be more susceptible dan females.<ref name="Golbe20142" /> Na dem no find association between PSP den any particular race, location, anaa occupation.<ref name="Golbe20142" /> == References == <references /> == External links == [[Category:Translated from MDWiki]] 7dopg04137piqc6pd8lx5y7rzf1gkxj 98085 98084 2026-05-14T17:48:17Z DaSupremo 9 /* Society den culture */ Improve article 98085 wikitext text/x-wiki {{Databox}} '''Progressive supranuclear palsy''' ('''PSP''') be a non late-onset neurodegenerative disease wey dey involve de gradual deterioration den death of specific volumes of de brain, dem link to 4-repeat tau pathology.<ref name="Golbe20142">{{cite journal |vauthors=Golbe LI |date=April 2014 |title=Progressive supranuclear palsy |journal=Seminars in Neurology |volume=34 |issue=2 |pages=151–9 |doi=10.1055/s-0034-1381736 |pmid=24963674 |doi-access=free}}</ref><ref name="ICD112">{{cite web |title=ICD-11 - Mortality and Morbidity Statistics |url=https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1493396558 |website=icd.who.int}}</ref><ref name=":0">{{Cite journal |last1=Boxer |first1=Adam L |last2=Yu |first2=Jin-Tai |last3=Golbe |first3=Lawrence I |last4=Litvan |first4=Irene |last5=Lang |first5=Anthony E |last6=Höglinger |first6=Günter U |date=July 2017 |title=Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches |journal=The Lancet Neurology |language=en |volume=16 |issue=7 |pages=552–563 |doi=10.1016/S1474-4422(17)30157-6|pmid=28653647 |pmc=5802400 }}</ref> De condition dey lead to symptoms wey dey include loss of balance, slowing of movement, difficulty dey move de eyes, den cognitive impairment.<ref name="Golbe20142" /> PSP fi be mistaken for oda types of neurodegeneration such as [[Parkinson's disease]], [[frontotemporal dementia]] den Alzheimer's disease. E be de second most common tauopathy behind [[Alzheimer's disease]]. De cause of de condition be uncertain, buh dey involve de accumulation of tau protein within de brain. Medications such as levodopa den amantadine fi be useful insyd sam cases.<ref name="Golbe20142" /> Na dem first describe PSP by Richardson, Steele, den Olszewski insyd 1963 as a form of progressive parkinsonism.<ref name=":3">{{Cite journal |last1=Lopez |first1=G. |last2=Bayulkem |first2=K. |last3=Hallett |first3=M. |date=October 2016 |title=Progressive supranuclear palsy (PSP): Richardson syndrome and other PSP variants |journal=Acta Neurologica Scandinavica |language=en |volume=134 |issue=4 |pages=242–249 |doi=10.1111/ane.12546|pmid=27070344 |pmc=7292631 }}</ref> However, de earliest known case wey dey present clinical dey feature consistent plus PSP, along plus pathological confirmation, na dem report insyd [[France]] insyd 1951.<ref name=":13">{{Cite journal |last1=Brusa |first1=Adolfo |last2=Stoehr |first2=Rolf |last3=Pramstaller |first3=Peter P. |date=March 2004 |title=Progressive supranuclear palsy: New disease or variant of postencephalitic parkinsonism? |url=https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.10699 |journal=Movement Disorders |language=en |volume=19 |issue=3 |pages=247–252 |doi=10.1002/mds.10699 |pmid=15022178 |issn=0885-3185}}</ref> Originally dem think am to be a more general type of atypical parkinsonism, PSP be linked to distinct clinical phenotypes wey dey include '''PSP-Richardson's syndrome (PSP-RS)''', wich be de most common sub-type of de disease.<ref name=":6">{{Cite journal |last1=Coughlin |first1=David G. |last2=Litvan |first2=Irene |date=April 2020 |title=Progressive supranuclear palsy: Advances in diagnosis and management |journal=Parkinsonism & Related Disorders |language=en |volume=73 |pages=105–116 |doi=10.1016/j.parkreldis.2020.04.014|pmid=32487421 |pmc=7462164 }}</ref> As PSP dey advance to a fully symptomatic stage, chaw PSP subtypes eventually dey exhibit de clinical characteristics of PSP-RS.<ref name=":0" /> PSP of all phenotypes get a prevalence of 18 per 100,000, whereas PSP-RS dey affect approximately 5 to 7 per 100,000 individuals.<ref name="Golbe20142" /><ref name=":0" /> De first symptoms typically dey occur at 60–70 years of age. Males slightly be more susceptible dan females.<ref name="Golbe20142" /> Na dem no find association between PSP den any particular race, location, anaa occupation.<ref name="Golbe20142" /> ==Society den culture== Der be several organizations around de world wey dey support PSP patients den de research into PSP den related diseases, such as corticobasal degeneration (CBD) den multiple system atrophy (MSA). * Canada: PSP Society of Canada<ref>[http://www.pspsocietycanada.ca/ PSP Society of Canada], re-linked 2020-01-20</ref> * France: Association PSP France, a nonprofit patient association dem set up insyd 1996<ref>[http://www.pspfrance.org/m-243-notre-histoire.html PSP France - Notre histoire] {{Webarchive|url=https://web.archive.org/web/20200605115303/http://www.pspfrance.org/m-243-notre-histoire.html |date=2020-06-05 }}, re-linked 2020-01-20</ref> *UK: PSPA, a national charity for information, patient support den research of PSP den CBD, dem set up insyd 1994<ref>{{cite web |title=About us |url=https://www.pspassociation.org.uk/about-us/ |publisher=PSPA |access-date=7 July 2025}}</ref> * Ireland: PSPAI, an organization wich dey aim to increase public awareness of PSP<ref>{{Cite web|url=https://pspaireland.ie/what-is-psp/|title = What is PSP|date = 18 October 2013}}</ref> * US: CurePSP, a nonprofit organization for promoting awareness, care den research of PSP, CBD, MSA "den oda prime of life neurodegenerative diseases"<ref>[https://www.psp.org/ CurePSP], re-linked 2020-01-20</ref> ===Insyd popular culture=== Insyd de 2020 American musical comedy-drama television series, ''Zoey's Extraordinary Playlist'', de title character ein poppie (Mitch Clarke, wey Peter Gallagher play) get PSP.<ref>{{Cite web|title='Zoey's Extraordinary Playlist' Boss on That Devastating Finale and Season 2 Plans|url=https://www.hollywoodreporter.com/live-feed/zoeys-extraordinary-playlist-finale-explained-austin-winsberg-interview-1292766|last=Bentley|first=Jean|date=May 3, 2020|website=The Hollywood Reporter|language=en|access-date=2020-05-04}}</ref> ===Notable cases=== * Dudley Moore (1935–2002): English actor, comedian, musician den composer * Peter Sarstedt (1941–2017): English singer den songwriter * Jesse Jackson (1941–2026) American activist * Phyllis Frelich (1944–2014): American Tony Award-winning actor * Richard Rainwater (1944–2015): American investor den philanthropist * Mary McCaslin (1946–2022): American singer den songwriter * Linda Ronstadt (b. 1946): American singer<ref>{{Cite magazine|title=Linda Ronstadt Has Found Another Voice|url=https://www.newyorker.com/culture/the-new-yorker-interview/linda-ronstadt-has-found-another-voice|last=Schulman|first=Michael|date=September 1, 2019|magazine=The New Yorker|language=en}}</ref> * Veena Sahasrabuddhe (1948–2016): Indian classical vocalist<ref>{{Cite magazine|title=Veena Sahasrabuddhe, Vocalist Who Stood at the Threshold of True Glory|url=https://thewire.in/the-arts/the-music-of-veena-sahasrabuddhe|last=Inamdar|first=Nikhil|date=July 7, 2016|magazine=The Wire|language=en}}</ref> * Jeff Golub (1955–2015): American Rock den Jazz guitar musician * Lee Wei Ling (1955–2024): Singaporean neurologist<ref>{{Cite news |last1=Tham |first1=Yuen-C |last2=Mujibah |first2=Fatimah |date=2024-10-09 |title=Lee Wei Ling, Lee Kuan Yew's daughter, dies at 69 |url=https://www.straitstimes.com/singapore/lee-kuan-yew-s-daughter-lee-wei-ling-dies-at-the-age-of-69 |access-date=2024-10-09 |work=The Straits Times |language=en |issn=0585-3923}}</ref> * Jennifer Wexton (b. 1968): former US Representative<ref>{{cite news |last1=Portnoy |first1=Jenna |title=Rep. Jennifer Wexton will not seek reelection as diagnosis changes |url=https://www.washingtonpost.com/dc-md-va/2023/09/18/jennifer-wexton-parkinsons-diagnosis-progressive-supranuclear-palsy/ |newspaper=Washington Post |date=18 September 2023}}</ref> == References == <references /> == External links == [[Category:Translated from MDWiki]] 0wp3j2gh3czn1j8t0g0x0roikpnrlp5 98086 98085 2026-05-14T17:50:03Z DaSupremo 9 Improve article 98086 wikitext text/x-wiki {{Databox}} '''Progressive supranuclear palsy''' ('''PSP''') be a non late-onset neurodegenerative disease wey dey involve de gradual deterioration den death of specific volumes of de brain, dem link to 4-repeat tau pathology.<ref name="Golbe20142">{{cite journal |vauthors=Golbe LI |date=April 2014 |title=Progressive supranuclear palsy |journal=Seminars in Neurology |volume=34 |issue=2 |pages=151–9 |doi=10.1055/s-0034-1381736 |pmid=24963674 |doi-access=free}}</ref><ref name="ICD112">{{cite web |title=ICD-11 - Mortality and Morbidity Statistics |url=https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1493396558 |website=icd.who.int}}</ref><ref name=":0">{{Cite journal |last1=Boxer |first1=Adam L |last2=Yu |first2=Jin-Tai |last3=Golbe |first3=Lawrence I |last4=Litvan |first4=Irene |last5=Lang |first5=Anthony E |last6=Höglinger |first6=Günter U |date=July 2017 |title=Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches |journal=The Lancet Neurology |language=en |volume=16 |issue=7 |pages=552–563 |doi=10.1016/S1474-4422(17)30157-6|pmid=28653647 |pmc=5802400 }}</ref> De condition dey lead to symptoms wey dey include loss of balance, slowing of movement, difficulty dey move de eyes, den cognitive impairment.<ref name="Golbe20142" /> PSP fi be mistaken for oda types of neurodegeneration such as [[Parkinson's disease]], [[frontotemporal dementia]] den Alzheimer's disease. E be de second most common tauopathy behind [[Alzheimer's disease]]. De cause of de condition be uncertain, buh dey involve de accumulation of tau protein within de brain. Medications such as levodopa den amantadine fi be useful insyd sam cases.<ref name="Golbe20142" /> Na dem first describe PSP by Richardson, Steele, den Olszewski insyd 1963 as a form of progressive parkinsonism.<ref name=":3">{{Cite journal |last1=Lopez |first1=G. |last2=Bayulkem |first2=K. |last3=Hallett |first3=M. |date=October 2016 |title=Progressive supranuclear palsy (PSP): Richardson syndrome and other PSP variants |journal=Acta Neurologica Scandinavica |language=en |volume=134 |issue=4 |pages=242–249 |doi=10.1111/ane.12546|pmid=27070344 |pmc=7292631 }}</ref> However, de earliest known case wey dey present clinical dey feature consistent plus PSP, along plus pathological confirmation, na dem report insyd [[France]] insyd 1951.<ref name=":13">{{Cite journal |last1=Brusa |first1=Adolfo |last2=Stoehr |first2=Rolf |last3=Pramstaller |first3=Peter P. |date=March 2004 |title=Progressive supranuclear palsy: New disease or variant of postencephalitic parkinsonism? |url=https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.10699 |journal=Movement Disorders |language=en |volume=19 |issue=3 |pages=247–252 |doi=10.1002/mds.10699 |pmid=15022178 |issn=0885-3185}}</ref> Originally dem think am to be a more general type of atypical parkinsonism, PSP be linked to distinct clinical phenotypes wey dey include '''PSP-Richardson's syndrome (PSP-RS)''', wich be de most common sub-type of de disease.<ref name=":6">{{Cite journal |last1=Coughlin |first1=David G. |last2=Litvan |first2=Irene |date=April 2020 |title=Progressive supranuclear palsy: Advances in diagnosis and management |journal=Parkinsonism & Related Disorders |language=en |volume=73 |pages=105–116 |doi=10.1016/j.parkreldis.2020.04.014|pmid=32487421 |pmc=7462164 }}</ref> As PSP dey advance to a fully symptomatic stage, chaw PSP subtypes eventually dey exhibit de clinical characteristics of PSP-RS.<ref name=":0" /> PSP of all phenotypes get a prevalence of 18 per 100,000, whereas PSP-RS dey affect approximately 5 to 7 per 100,000 individuals.<ref name="Golbe20142" /><ref name=":0" /> De first symptoms typically dey occur at 60–70 years of age. Males slightly be more susceptible dan females.<ref name="Golbe20142" /> Na dem no find association between PSP den any particular race, location, anaa occupation.<ref name="Golbe20142" /> ==Society den culture== Der be several organizations around de world wey dey support PSP patients den de research into PSP den related diseases, such as corticobasal degeneration (CBD) den multiple system atrophy (MSA). * Canada: PSP Society of Canada<ref>[http://www.pspsocietycanada.ca/ PSP Society of Canada], re-linked 2020-01-20</ref> * France: Association PSP France, a nonprofit patient association dem set up insyd 1996<ref>[http://www.pspfrance.org/m-243-notre-histoire.html PSP France - Notre histoire] {{Webarchive|url=https://web.archive.org/web/20200605115303/http://www.pspfrance.org/m-243-notre-histoire.html |date=2020-06-05 }}, re-linked 2020-01-20</ref> *UK: PSPA, a national charity for information, patient support den research of PSP den CBD, dem set up insyd 1994<ref>{{cite web |title=About us |url=https://www.pspassociation.org.uk/about-us/ |publisher=PSPA |access-date=7 July 2025}}</ref> * Ireland: PSPAI, an organization wich dey aim to increase public awareness of PSP<ref>{{Cite web|url=https://pspaireland.ie/what-is-psp/|title = What is PSP|date = 18 October 2013}}</ref> * US: CurePSP, a nonprofit organization for promoting awareness, care den research of PSP, CBD, MSA "den oda prime of life neurodegenerative diseases"<ref>[https://www.psp.org/ CurePSP], re-linked 2020-01-20</ref> ===Insyd popular culture=== Insyd de 2020 American musical comedy-drama television series, ''Zoey's Extraordinary Playlist'', de title character ein poppie (Mitch Clarke, wey Peter Gallagher play) get PSP.<ref>{{Cite web|title='Zoey's Extraordinary Playlist' Boss on That Devastating Finale and Season 2 Plans|url=https://www.hollywoodreporter.com/live-feed/zoeys-extraordinary-playlist-finale-explained-austin-winsberg-interview-1292766|last=Bentley|first=Jean|date=May 3, 2020|website=The Hollywood Reporter|language=en|access-date=2020-05-04}}</ref> ===Notable cases=== * Dudley Moore (1935–2002): English actor, comedian, musician den composer * Peter Sarstedt (1941–2017): English singer den songwriter * Jesse Jackson (1941–2026) American activist * Phyllis Frelich (1944–2014): American Tony Award-winning actor * Richard Rainwater (1944–2015): American investor den philanthropist * Mary McCaslin (1946–2022): American singer den songwriter * Linda Ronstadt (b. 1946): American singer<ref>{{Cite magazine|title=Linda Ronstadt Has Found Another Voice|url=https://www.newyorker.com/culture/the-new-yorker-interview/linda-ronstadt-has-found-another-voice|last=Schulman|first=Michael|date=September 1, 2019|magazine=The New Yorker|language=en}}</ref> * Veena Sahasrabuddhe (1948–2016): Indian classical vocalist<ref>{{Cite magazine|title=Veena Sahasrabuddhe, Vocalist Who Stood at the Threshold of True Glory|url=https://thewire.in/the-arts/the-music-of-veena-sahasrabuddhe|last=Inamdar|first=Nikhil|date=July 7, 2016|magazine=The Wire|language=en}}</ref> * Jeff Golub (1955–2015): American Rock den Jazz guitar musician * Lee Wei Ling (1955–2024): Singaporean neurologist<ref>{{Cite news |last1=Tham |first1=Yuen-C |last2=Mujibah |first2=Fatimah |date=2024-10-09 |title=Lee Wei Ling, Lee Kuan Yew's daughter, dies at 69 |url=https://www.straitstimes.com/singapore/lee-kuan-yew-s-daughter-lee-wei-ling-dies-at-the-age-of-69 |access-date=2024-10-09 |work=The Straits Times |language=en |issn=0585-3923}}</ref> * Jennifer Wexton (b. 1968): former US Representative<ref>{{cite news |last1=Portnoy |first1=Jenna |title=Rep. Jennifer Wexton will not seek reelection as diagnosis changes |url=https://www.washingtonpost.com/dc-md-va/2023/09/18/jennifer-wexton-parkinsons-diagnosis-progressive-supranuclear-palsy/ |newspaper=Washington Post |date=18 September 2023}}</ref> == References == <references /> == External links == {{Commons}}{{DEFAULTSORT:Progressive Supranuclear Palsy}} [[Category:Cognitive disorders]] [[Category:Corticobasal syndrome]] [[Category:Extrapyramidal den movement disorders]] [[Category:Rare diseases]] [[Category:Syndromes]] [[Category:Translated from MDWiki]] 0xm1onxgfsfe860ensri4zrsom9uc1d 98087 98086 2026-05-14T17:50:40Z DaSupremo 9 Add category 98087 wikitext text/x-wiki {{Databox}} '''Progressive supranuclear palsy''' ('''PSP''') be a non late-onset neurodegenerative disease wey dey involve de gradual deterioration den death of specific volumes of de brain, dem link to 4-repeat tau pathology.<ref name="Golbe20142">{{cite journal |vauthors=Golbe LI |date=April 2014 |title=Progressive supranuclear palsy |journal=Seminars in Neurology |volume=34 |issue=2 |pages=151–9 |doi=10.1055/s-0034-1381736 |pmid=24963674 |doi-access=free}}</ref><ref name="ICD112">{{cite web |title=ICD-11 - Mortality and Morbidity Statistics |url=https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1493396558 |website=icd.who.int}}</ref><ref name=":0">{{Cite journal |last1=Boxer |first1=Adam L |last2=Yu |first2=Jin-Tai |last3=Golbe |first3=Lawrence I |last4=Litvan |first4=Irene |last5=Lang |first5=Anthony E |last6=Höglinger |first6=Günter U |date=July 2017 |title=Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches |journal=The Lancet Neurology |language=en |volume=16 |issue=7 |pages=552–563 |doi=10.1016/S1474-4422(17)30157-6|pmid=28653647 |pmc=5802400 }}</ref> De condition dey lead to symptoms wey dey include loss of balance, slowing of movement, difficulty dey move de eyes, den cognitive impairment.<ref name="Golbe20142" /> PSP fi be mistaken for oda types of neurodegeneration such as [[Parkinson's disease]], [[frontotemporal dementia]] den Alzheimer's disease. E be de second most common tauopathy behind [[Alzheimer's disease]]. De cause of de condition be uncertain, buh dey involve de accumulation of tau protein within de brain. Medications such as levodopa den amantadine fi be useful insyd sam cases.<ref name="Golbe20142" /> Na dem first describe PSP by Richardson, Steele, den Olszewski insyd 1963 as a form of progressive parkinsonism.<ref name=":3">{{Cite journal |last1=Lopez |first1=G. |last2=Bayulkem |first2=K. |last3=Hallett |first3=M. |date=October 2016 |title=Progressive supranuclear palsy (PSP): Richardson syndrome and other PSP variants |journal=Acta Neurologica Scandinavica |language=en |volume=134 |issue=4 |pages=242–249 |doi=10.1111/ane.12546|pmid=27070344 |pmc=7292631 }}</ref> However, de earliest known case wey dey present clinical dey feature consistent plus PSP, along plus pathological confirmation, na dem report insyd [[France]] insyd 1951.<ref name=":13">{{Cite journal |last1=Brusa |first1=Adolfo |last2=Stoehr |first2=Rolf |last3=Pramstaller |first3=Peter P. |date=March 2004 |title=Progressive supranuclear palsy: New disease or variant of postencephalitic parkinsonism? |url=https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.10699 |journal=Movement Disorders |language=en |volume=19 |issue=3 |pages=247–252 |doi=10.1002/mds.10699 |pmid=15022178 |issn=0885-3185}}</ref> Originally dem think am to be a more general type of atypical parkinsonism, PSP be linked to distinct clinical phenotypes wey dey include '''PSP-Richardson's syndrome (PSP-RS)''', wich be de most common sub-type of de disease.<ref name=":6">{{Cite journal |last1=Coughlin |first1=David G. |last2=Litvan |first2=Irene |date=April 2020 |title=Progressive supranuclear palsy: Advances in diagnosis and management |journal=Parkinsonism & Related Disorders |language=en |volume=73 |pages=105–116 |doi=10.1016/j.parkreldis.2020.04.014|pmid=32487421 |pmc=7462164 }}</ref> As PSP dey advance to a fully symptomatic stage, chaw PSP subtypes eventually dey exhibit de clinical characteristics of PSP-RS.<ref name=":0" /> PSP of all phenotypes get a prevalence of 18 per 100,000, whereas PSP-RS dey affect approximately 5 to 7 per 100,000 individuals.<ref name="Golbe20142" /><ref name=":0" /> De first symptoms typically dey occur at 60–70 years of age. Males slightly be more susceptible dan females.<ref name="Golbe20142" /> Na dem no find association between PSP den any particular race, location, anaa occupation.<ref name="Golbe20142" /> ==Society den culture== Der be several organizations around de world wey dey support PSP patients den de research into PSP den related diseases, such as corticobasal degeneration (CBD) den multiple system atrophy (MSA). * Canada: PSP Society of Canada<ref>[http://www.pspsocietycanada.ca/ PSP Society of Canada], re-linked 2020-01-20</ref> * France: Association PSP France, a nonprofit patient association dem set up insyd 1996<ref>[http://www.pspfrance.org/m-243-notre-histoire.html PSP France - Notre histoire] {{Webarchive|url=https://web.archive.org/web/20200605115303/http://www.pspfrance.org/m-243-notre-histoire.html |date=2020-06-05 }}, re-linked 2020-01-20</ref> *UK: PSPA, a national charity for information, patient support den research of PSP den CBD, dem set up insyd 1994<ref>{{cite web |title=About us |url=https://www.pspassociation.org.uk/about-us/ |publisher=PSPA |access-date=7 July 2025}}</ref> * Ireland: PSPAI, an organization wich dey aim to increase public awareness of PSP<ref>{{Cite web|url=https://pspaireland.ie/what-is-psp/|title = What is PSP|date = 18 October 2013}}</ref> * US: CurePSP, a nonprofit organization for promoting awareness, care den research of PSP, CBD, MSA "den oda prime of life neurodegenerative diseases"<ref>[https://www.psp.org/ CurePSP], re-linked 2020-01-20</ref> ===Insyd popular culture=== Insyd de 2020 American musical comedy-drama television series, ''Zoey's Extraordinary Playlist'', de title character ein poppie (Mitch Clarke, wey Peter Gallagher play) get PSP.<ref>{{Cite web|title='Zoey's Extraordinary Playlist' Boss on That Devastating Finale and Season 2 Plans|url=https://www.hollywoodreporter.com/live-feed/zoeys-extraordinary-playlist-finale-explained-austin-winsberg-interview-1292766|last=Bentley|first=Jean|date=May 3, 2020|website=The Hollywood Reporter|language=en|access-date=2020-05-04}}</ref> ===Notable cases=== * Dudley Moore (1935–2002): English actor, comedian, musician den composer * Peter Sarstedt (1941–2017): English singer den songwriter * Jesse Jackson (1941–2026) American activist * Phyllis Frelich (1944–2014): American Tony Award-winning actor * Richard Rainwater (1944–2015): American investor den philanthropist * Mary McCaslin (1946–2022): American singer den songwriter * Linda Ronstadt (b. 1946): American singer<ref>{{Cite magazine|title=Linda Ronstadt Has Found Another Voice|url=https://www.newyorker.com/culture/the-new-yorker-interview/linda-ronstadt-has-found-another-voice|last=Schulman|first=Michael|date=September 1, 2019|magazine=The New Yorker|language=en}}</ref> * Veena Sahasrabuddhe (1948–2016): Indian classical vocalist<ref>{{Cite magazine|title=Veena Sahasrabuddhe, Vocalist Who Stood at the Threshold of True Glory|url=https://thewire.in/the-arts/the-music-of-veena-sahasrabuddhe|last=Inamdar|first=Nikhil|date=July 7, 2016|magazine=The Wire|language=en}}</ref> * Jeff Golub (1955–2015): American Rock den Jazz guitar musician * Lee Wei Ling (1955–2024): Singaporean neurologist<ref>{{Cite news |last1=Tham |first1=Yuen-C |last2=Mujibah |first2=Fatimah |date=2024-10-09 |title=Lee Wei Ling, Lee Kuan Yew's daughter, dies at 69 |url=https://www.straitstimes.com/singapore/lee-kuan-yew-s-daughter-lee-wei-ling-dies-at-the-age-of-69 |access-date=2024-10-09 |work=The Straits Times |language=en |issn=0585-3923}}</ref> * Jennifer Wexton (b. 1968): former US Representative<ref>{{cite news |last1=Portnoy |first1=Jenna |title=Rep. Jennifer Wexton will not seek reelection as diagnosis changes |url=https://www.washingtonpost.com/dc-md-va/2023/09/18/jennifer-wexton-parkinsons-diagnosis-progressive-supranuclear-palsy/ |newspaper=Washington Post |date=18 September 2023}}</ref> == References == <references /> == External links == {{Commons}}{{DEFAULTSORT:Progressive Supranuclear Palsy}} [[Category:Cognitive disorders]] [[Category:Corticobasal syndrome]] [[Category:Extrapyramidal den movement disorders]] [[Category:Rare diseases]] [[Category:Syndromes]] [[Category:Translated from MDWiki]] [[Category:Diseases dem name after discoverers]] k5c5jyws5cq7x65slt5rr64fpfkox3f 14 26868 98088 2026-05-14T17:50:51Z DaSupremo 9 Fresh category 98088 wikitext text/x-wiki phoiac9h4m842xq45sp7s6u21eteeq1 0 26869 98089 2026-05-14T17:53:19Z DaSupremo 9 Created by translating the page [[:mdwiki:Special:Redirect/revision/1459367|Variant Creutzfeldt–Jakob disease]] to:gpe #mdwikicx 98089 wikitext text/x-wiki [[Category:Translated from MDWiki]] r0gf7axtnvt68k0p85plnlehx64o08u 98091 98089 2026-05-14T18:00:44Z DaSupremo 9 Improve article 98091 wikitext text/x-wiki {{Databox}} '''Variant Creutzfeldt–Jakob disease''' ('''vCJD'''), dem formerly know as '''new variant Creutzfeldt–Jakob disease''' ('''nvCJD''') wey dem refer to am colloquially as "'''Creutzfeldt–Jakob Disease'''", "'''mad cow disease'''" anaa "'''human mad cow disease'''" (to distinguish am from ein [[Bovine spongiform encephalopathy|BSE]] counterpart), be a fatal type of brain disease within de transmissible spongiform encephalopathy family.<ref name="Iron20122">{{cite journal |vauthors=Ironside JW |date=2012 |title=Variant Creutzfeldt-Jakob disease: an update |journal=Folia Neuropathologica |volume=50 |issue=1 |pages=50–56 |pmid=22505363}}</ref> Initial symptoms dey include [[Mental disorder|psychiatric problems]], behavioral changes, den painful sensations.<ref name="CDC2015Comp" /> Insyd de later stages of de illness, patients fi exhibit poor coordination, [[dementia]] den involuntary movements.<ref name="CDC2015Criteria2">{{cite web |date=November 2012 |title=Clinical Overview of Variant Creutzfeldt-Jakob Disease |url=https://www.cdc.gov/variant-creutzfeldt-jakob/hcp/clinical-overview/?CDC_AAref_Val=https://www.cdc.gov/prions/vcjd/diagnostic-criteria.html |access-date=February 24, 2026 |website=CDC |language=en-us}}</ref> De length of time between exposure den de development of symptoms be unclear, buh e be believed to be years to decades.<ref name="CDC2015Diag">{{cite web|title=Classic CJD versus Variant CJD|url=https://www.cdc.gov/prions/vcjd/classic-variant.html|archive-url=https://web.archive.org/web/20150831053519/http://www.cdc.gov/prions/vcjd/classic-variant.html|url-status=dead|archive-date=August 31, 2015|website=CDC|access-date=23 January 2018|language=en-us|date=11 February 2015}} </ref> Average life expectancy dey follow de onset of symptoms be 13 months.<ref name="CDC2015Comp">{{cite web|title=Clinical and Pathologic Characteristics {{!}} Variant Creutzfeldt-Jakob Disease, Classic (CJD)|url=https://www.cdc.gov/prions/vcjd/clinical-pathologic-characteristics.html|website=CDC|access-date=22 January 2018|language=en-us|date=10 February 2015}}</ref> == References == [[Category:Translated from MDWiki]] <references /> == External links == hyxzri8emzr9nbyt4m4463gds69lbs6 98102 98091 2026-05-14T21:45:37Z DaSupremo 9 Improve article 98102 wikitext text/x-wiki {{Databox}} '''Variant Creutzfeldt–Jakob disease''' ('''vCJD'''), dem formerly know as '''new variant Creutzfeldt–Jakob disease''' ('''nvCJD''') wey dem refer to am colloquially as "'''Creutzfeldt–Jakob Disease'''", "'''mad cow disease'''" anaa "'''human mad cow disease'''" (to distinguish am from ein [[Bovine spongiform encephalopathy|BSE]] counterpart), be a fatal type of brain disease within de transmissible spongiform encephalopathy family.<ref name="Iron20122">{{cite journal |vauthors=Ironside JW |date=2012 |title=Variant Creutzfeldt-Jakob disease: an update |journal=Folia Neuropathologica |volume=50 |issue=1 |pages=50–56 |pmid=22505363}}</ref> Initial symptoms dey include [[Mental disorder|psychiatric problems]], behavioral changes, den painful sensations.<ref name="CDC2015Comp" /> Insyd de later stages of de illness, patients fi exhibit poor coordination, [[dementia]] den involuntary movements.<ref name="CDC2015Criteria2">{{cite web |date=November 2012 |title=Clinical Overview of Variant Creutzfeldt-Jakob Disease |url=https://www.cdc.gov/variant-creutzfeldt-jakob/hcp/clinical-overview/?CDC_AAref_Val=https://www.cdc.gov/prions/vcjd/diagnostic-criteria.html |access-date=February 24, 2026 |website=CDC |language=en-us}}</ref> De length of time between exposure den de development of symptoms be unclear, buh e be believed to be years to decades.<ref name="CDC2015Diag">{{cite web|title=Classic CJD versus Variant CJD|url=https://www.cdc.gov/prions/vcjd/classic-variant.html|archive-url=https://web.archive.org/web/20150831053519/http://www.cdc.gov/prions/vcjd/classic-variant.html|url-status=dead|archive-date=August 31, 2015|website=CDC|access-date=23 January 2018|language=en-us|date=11 February 2015}} </ref> Average life expectancy dey follow de onset of symptoms be 13 months.<ref name="CDC2015Comp">{{cite web|title=Clinical and Pathologic Characteristics {{!}} Variant Creutzfeldt-Jakob Disease, Classic (CJD)|url=https://www.cdc.gov/prions/vcjd/clinical-pathologic-characteristics.html|website=CDC|access-date=22 January 2018|language=en-us|date=10 February 2015}}</ref> E be caused by prions, wich be misfolded proteins.<ref name="CDC2015About">{{cite web|title=About vCJD|url=https://www.cdc.gov/prions/vcjd/about.html|website=CDC|access-date=22 January 2018|language=en-us|date=10 February 2015}}</ref> Spread be believed to be primarily secof dem chop beef wey be infected plus BSE.<ref name="Iron2012"/><ref name="CDC2015About"/> Infection sanso be believed to require a specific genetic susceptibility.<ref name="Iron2010">{{cite journal | vauthors = Ironside JW | title = Variant Creutzfeldt-Jakob disease | journal = Haemophilia | volume = 16 | issue = Suppl 5 | pages = 175–180 | date = July 2010 | pmid = 20590878 | doi = 10.1111/j.1365-2516.2010.02317.x | s2cid = 24635924 | doi-access = free }}</ref><ref name="Iron2012">{{cite journal | vauthors = Ironside JW | title = Variant Creutzfeldt-Jakob disease: an update | journal = Folia Neuropathologica | volume = 50 | issue = 1 | pages = 50–56 | date = 2012 | pmid = 22505363 }}</ref> Spread potentially sanso fi occur via blood products anaa contaminated surgical equipment.<ref name=":0">{{cite book| vauthors = Ferri FF |title=Ferri's Clinical Advisor 2018 E-Book: 5 Books in 1|date=2017|publisher=Elsevier Health Sciences|isbn=9780323529570|page=343|url=https://books.google.com/books?id=wGclDwAAQBAJ&pg=PA343-IA4|language=en}}</ref> Diagnosis be by brain biopsy buh fi be suspected based on certain oda criteria.<ref name="CDC2015Diag"/> E be different from typical [[Creutzfeldt–Jakob disease]], though both be secof prions.<ref name="CDC2015About"/> == References == <references /> == External links == [[Category:Translated from MDWiki]] e2nt1gbt7fi4vh25icomz6fzfhh7apy 98103 98102 2026-05-14T21:53:21Z DaSupremo 9 Improve article 98103 wikitext text/x-wiki {{Databox}} '''Variant Creutzfeldt–Jakob disease''' ('''vCJD'''), dem formerly know as '''new variant Creutzfeldt–Jakob disease''' ('''nvCJD''') wey dem refer to am colloquially as "'''Creutzfeldt–Jakob Disease'''", "'''mad cow disease'''" anaa "'''human mad cow disease'''" (to distinguish am from ein [[Bovine spongiform encephalopathy|BSE]] counterpart), be a fatal type of brain disease within de transmissible spongiform encephalopathy family.<ref name="Iron20122">{{cite journal |vauthors=Ironside JW |date=2012 |title=Variant Creutzfeldt-Jakob disease: an update |journal=Folia Neuropathologica |volume=50 |issue=1 |pages=50–56 |pmid=22505363}}</ref> Initial symptoms dey include [[Mental disorder|psychiatric problems]], behavioral changes, den painful sensations.<ref name="CDC2015Comp" /> Insyd de later stages of de illness, patients fi exhibit poor coordination, [[dementia]] den involuntary movements.<ref name="CDC2015Criteria2">{{cite web |date=November 2012 |title=Clinical Overview of Variant Creutzfeldt-Jakob Disease |url=https://www.cdc.gov/variant-creutzfeldt-jakob/hcp/clinical-overview/?CDC_AAref_Val=https://www.cdc.gov/prions/vcjd/diagnostic-criteria.html |access-date=February 24, 2026 |website=CDC |language=en-us}}</ref> De length of time between exposure den de development of symptoms be unclear, buh e be believed to be years to decades.<ref name="CDC2015Diag">{{cite web|title=Classic CJD versus Variant CJD|url=https://www.cdc.gov/prions/vcjd/classic-variant.html|archive-url=https://web.archive.org/web/20150831053519/http://www.cdc.gov/prions/vcjd/classic-variant.html|url-status=dead|archive-date=August 31, 2015|website=CDC|access-date=23 January 2018|language=en-us|date=11 February 2015}} </ref> Average life expectancy dey follow de onset of symptoms be 13 months.<ref name="CDC2015Comp">{{cite web|title=Clinical and Pathologic Characteristics {{!}} Variant Creutzfeldt-Jakob Disease, Classic (CJD)|url=https://www.cdc.gov/prions/vcjd/clinical-pathologic-characteristics.html|website=CDC|access-date=22 January 2018|language=en-us|date=10 February 2015}}</ref> E be caused by prions, wich be misfolded proteins.<ref name="CDC2015About">{{cite web|title=About vCJD|url=https://www.cdc.gov/prions/vcjd/about.html|website=CDC|access-date=22 January 2018|language=en-us|date=10 February 2015}}</ref> Spread be believed to be primarily secof dem chop beef wey be infected plus BSE.<ref name="Iron2012"/><ref name="CDC2015About"/> Infection sanso be believed to require a specific genetic susceptibility.<ref name="Iron2010">{{cite journal | vauthors = Ironside JW | title = Variant Creutzfeldt-Jakob disease | journal = Haemophilia | volume = 16 | issue = Suppl 5 | pages = 175–180 | date = July 2010 | pmid = 20590878 | doi = 10.1111/j.1365-2516.2010.02317.x | s2cid = 24635924 | doi-access = free }}</ref><ref name="Iron2012">{{cite journal | vauthors = Ironside JW | title = Variant Creutzfeldt-Jakob disease: an update | journal = Folia Neuropathologica | volume = 50 | issue = 1 | pages = 50–56 | date = 2012 | pmid = 22505363 }}</ref> Spread potentially sanso fi occur via blood products anaa contaminated surgical equipment.<ref name=":0">{{cite book| vauthors = Ferri FF |title=Ferri's Clinical Advisor 2018 E-Book: 5 Books in 1|date=2017|publisher=Elsevier Health Sciences|isbn=9780323529570|page=343|url=https://books.google.com/books?id=wGclDwAAQBAJ&pg=PA343-IA4|language=en}}</ref> Diagnosis be by brain biopsy buh fi be suspected based on certain oda criteria.<ref name="CDC2015Diag"/> E be different from typical [[Creutzfeldt–Jakob disease]], though both be secof prions.<ref name="CDC2015About"/> Treatment give vCJD dey involve supportive care.<ref name="CDC2015Tx">{{cite web|title=Treatment Variant Creutzfeldt-Jakob Disease|url=https://www.cdc.gov/prions/vcjd/treatment.html|website=CDC|access-date=23 January 2018|language=en-us|date=10 February 2015}}</ref> As of 2020, 178 cases of vCJD be recorded insyd de [[United Kingdom]],<ref name=":1">{{cite journal | vauthors = Gill ON, Spencer Y, Richard-Loendt A, Kelly C, Brown D, Sinka K, Andrews N, Dabaghian R, Simmons M, Edwards P, Bellerby P, Everest DJ, McCall M, McCardle LM, Linehan J, Mead S, Hilton DA, Ironside JW, Brandner S | display-authors = 6 | title = Prevalence in Britain of abnormal prion protein in human appendices before and after exposure to the cattle BSE epizootic | journal = Acta Neuropathologica | volume = 139 | issue = 6 | pages = 965–976 | date = June 2020 | pmid = 32232565 | pmc = 7244468 | doi = 10.1007/s00401-020-02153-7 }}</ref> secof a 1990s outbreak, den 50 cases insyd de rest of de world.<ref name="Iron2012"/> De disease cam be less common since 2000.<ref name="Iron2012"/> De typical age of onset be less dan 30 years old.<ref name="CDC2015Diag"/> E be first identified insyd 1996 by de National CJD Surveillance Unit insyd Edinburgh, Scotland.<ref name="Iron2012"/> Controversial research by Harash Narang, wey work as a virologist at de Public Health Laboratory Service (PHLS) suggest a link between BSE den CJD as early as 1989.<ref>{{Cite web |date=1999-08-10 |title=How a scientist obtained thousands for a BSE test he could not prove |url=https://www.independent.co.uk/news/how-a-scientist-obtained-thousands-for-a-bse-test-he-could-not-prove-1112025.html |access-date=2026-03-18 |website=The Independent |language=en}}</ref><ref>{{Cite web |date=1996-03-21 |title=Thousands may have caught CJD during three years before Government clamped down on meat Deadly legacy of infection |url=https://www.heraldscotland.com/news/12051687.thousands-may-have-caught-cjd-during-three-years-before-government-clamped-down-on-meat-deadly-legacy-of-infection/ |access-date=2026-03-18 |website=The Herald |language=en}}</ref> == References == <references /> == External links == [[Category:Translated from MDWiki]] 8tdi4wztuzbdp080ng3yf6ohszqy36y 98104 98103 2026-05-14T22:03:01Z DaSupremo 9 Improve article 98104 wikitext text/x-wiki {{Databox}} '''Variant Creutzfeldt–Jakob disease''' ('''vCJD'''), dem formerly know as '''new variant Creutzfeldt–Jakob disease''' ('''nvCJD''') wey dem refer to am colloquially as "'''Creutzfeldt–Jakob Disease'''", "'''mad cow disease'''" anaa "'''human mad cow disease'''" (to distinguish am from ein [[Bovine spongiform encephalopathy|BSE]] counterpart), be a fatal type of brain disease within de transmissible spongiform encephalopathy family.<ref name="Iron20122">{{cite journal |vauthors=Ironside JW |date=2012 |title=Variant Creutzfeldt-Jakob disease: an update |journal=Folia Neuropathologica |volume=50 |issue=1 |pages=50–56 |pmid=22505363}}</ref> Initial symptoms dey include [[Mental disorder|psychiatric problems]], behavioral changes, den painful sensations.<ref name="CDC2015Comp" /> Insyd de later stages of de illness, patients fi exhibit poor coordination, [[dementia]] den involuntary movements.<ref name="CDC2015Criteria2">{{cite web |date=November 2012 |title=Clinical Overview of Variant Creutzfeldt-Jakob Disease |url=https://www.cdc.gov/variant-creutzfeldt-jakob/hcp/clinical-overview/?CDC_AAref_Val=https://www.cdc.gov/prions/vcjd/diagnostic-criteria.html |access-date=February 24, 2026 |website=CDC |language=en-us}}</ref> De length of time between exposure den de development of symptoms be unclear, buh e be believed to be years to decades.<ref name="CDC2015Diag">{{cite web|title=Classic CJD versus Variant CJD|url=https://www.cdc.gov/prions/vcjd/classic-variant.html|archive-url=https://web.archive.org/web/20150831053519/http://www.cdc.gov/prions/vcjd/classic-variant.html|url-status=dead|archive-date=August 31, 2015|website=CDC|access-date=23 January 2018|language=en-us|date=11 February 2015}} </ref> Average life expectancy dey follow de onset of symptoms be 13 months.<ref name="CDC2015Comp">{{cite web|title=Clinical and Pathologic Characteristics {{!}} Variant Creutzfeldt-Jakob Disease, Classic (CJD)|url=https://www.cdc.gov/prions/vcjd/clinical-pathologic-characteristics.html|website=CDC|access-date=22 January 2018|language=en-us|date=10 February 2015}}</ref> E be caused by prions, wich be misfolded proteins.<ref name="CDC2015About">{{cite web|title=About vCJD|url=https://www.cdc.gov/prions/vcjd/about.html|website=CDC|access-date=22 January 2018|language=en-us|date=10 February 2015}}</ref> Spread be believed to be primarily secof dem chop beef wey be infected plus BSE.<ref name="Iron2012"/><ref name="CDC2015About"/> Infection sanso be believed to require a specific genetic susceptibility.<ref name="Iron2010">{{cite journal | vauthors = Ironside JW | title = Variant Creutzfeldt-Jakob disease | journal = Haemophilia | volume = 16 | issue = Suppl 5 | pages = 175–180 | date = July 2010 | pmid = 20590878 | doi = 10.1111/j.1365-2516.2010.02317.x | s2cid = 24635924 | doi-access = free }}</ref><ref name="Iron2012">{{cite journal | vauthors = Ironside JW | title = Variant Creutzfeldt-Jakob disease: an update | journal = Folia Neuropathologica | volume = 50 | issue = 1 | pages = 50–56 | date = 2012 | pmid = 22505363 }}</ref> Spread potentially sanso fi occur via blood products anaa contaminated surgical equipment.<ref name=":0">{{cite book| vauthors = Ferri FF |title=Ferri's Clinical Advisor 2018 E-Book: 5 Books in 1|date=2017|publisher=Elsevier Health Sciences|isbn=9780323529570|page=343|url=https://books.google.com/books?id=wGclDwAAQBAJ&pg=PA343-IA4|language=en}}</ref> Diagnosis be by brain biopsy buh fi be suspected based on certain oda criteria.<ref name="CDC2015Diag"/> E be different from typical [[Creutzfeldt–Jakob disease]], though both be secof prions.<ref name="CDC2015About"/> Treatment give vCJD dey involve supportive care.<ref name="CDC2015Tx">{{cite web|title=Treatment Variant Creutzfeldt-Jakob Disease|url=https://www.cdc.gov/prions/vcjd/treatment.html|website=CDC|access-date=23 January 2018|language=en-us|date=10 February 2015}}</ref> As of 2020, 178 cases of vCJD be recorded insyd de [[United Kingdom]],<ref name=":1">{{cite journal | vauthors = Gill ON, Spencer Y, Richard-Loendt A, Kelly C, Brown D, Sinka K, Andrews N, Dabaghian R, Simmons M, Edwards P, Bellerby P, Everest DJ, McCall M, McCardle LM, Linehan J, Mead S, Hilton DA, Ironside JW, Brandner S | display-authors = 6 | title = Prevalence in Britain of abnormal prion protein in human appendices before and after exposure to the cattle BSE epizootic | journal = Acta Neuropathologica | volume = 139 | issue = 6 | pages = 965–976 | date = June 2020 | pmid = 32232565 | pmc = 7244468 | doi = 10.1007/s00401-020-02153-7 }}</ref> secof a 1990s outbreak, den 50 cases insyd de rest of de world.<ref name="Iron2012"/> De disease cam be less common since 2000.<ref name="Iron2012"/> De typical age of onset be less dan 30 years old.<ref name="CDC2015Diag"/> E be first identified insyd 1996 by de National CJD Surveillance Unit insyd Edinburgh, Scotland.<ref name="Iron2012"/> Controversial research by Harash Narang, wey work as a virologist at de Public Health Laboratory Service (PHLS) suggest a link between BSE den CJD as early as 1989.<ref>{{Cite web |date=1999-08-10 |title=How a scientist obtained thousands for a BSE test he could not prove |url=https://www.independent.co.uk/news/how-a-scientist-obtained-thousands-for-a-bse-test-he-could-not-prove-1112025.html |access-date=2026-03-18 |website=The Independent |language=en}}</ref><ref>{{Cite web |date=1996-03-21 |title=Thousands may have caught CJD during three years before Government clamped down on meat Deadly legacy of infection |url=https://www.heraldscotland.com/news/12051687.thousands-may-have-caught-cjd-during-three-years-before-government-clamped-down-on-meat-deadly-legacy-of-infection/ |access-date=2026-03-18 |website=The Herald |language=en}}</ref> == References == <references /> == External links == {{Commons}} [[Category:Diseases dem name after discoverers]] [[Category:Foodborne illnesses]] [[Category:Rare diseases]] [[Category:Transmissible spongiform encephalopathies]] [[Category:Zoonoses]] [[Category:Translated from MDWiki]] lqxyac1v2dld5qaxb7xvr4dwfg78y1q 0 26870 98090 2026-05-14T17:53:51Z DaSupremo 9 Created by translating the page [[:mdwiki:Special:Redirect/revision/1496115|Polio vaccine]] to:gpe #mdwikicx 98090 wikitext text/x-wiki [[Category:Translated from MDWiki]] r0gf7axtnvt68k0p85plnlehx64o08u 98105 98090 2026-05-14T22:39:10Z DaSupremo 9 Improve article 98105 wikitext text/x-wiki {{Databox}} '''Polio vaccine''' be a vaccine dem use to prevent poliomyelitis (polio).<ref name="WHO20162">{{cite journal |date=2016 |title=Polio vaccines: WHO position paper – March, 2016 |journal=Weekly Epidemiological Record |volume=91 |issue=12 |pages=145–68 |hdl=10665/254399 |pmid=27039410 |hdl-access=free}}</ref><ref name=WHO2022>{{cite journal | title = Polio vaccines: WHO position paper – June 2022 | journal = Weekly Epidemiological Record | volume = 97 | issue = 25 | pages = 277–300 | date = 2022 | hdl=10665/357168 | hdl-access = free}}</ref> Two types be used: an inactivated poliovirus wey be given by injection (IPV) den a weakened poliovirus wey be given by mouth (OPV).<ref name="WHO20162" /> De World Health Organization (WHO) dey recommend all kiddies be fully vaccinated against polio.<ref name="WHO20162" /> De two vaccines eliminate polio from chaw of de world,<ref name="Aylward_2006">{{cite journal|vauthors=Aylward RB|year=2006|title=Eradicating polio: today's challenges and tomorrow's legacy|journal=Annals of Tropical Medicine and Parasitology|volume=100|issue=5–6|pages=401–413|doi=10.1179/136485906X97354|pmid=16899145|s2cid=25327986}}</ref><ref>{{cite journal|vauthors=Schonberger LB, Kaplan J, Kim-Farley R, Moore M, Eddins DL, Hatch M|year=1984|title=Control of paralytic poliomyelitis in the United States|journal=Reviews of Infectious Diseases|volume=6 | issue = Suppl 2|pages=S424–S426|doi=10.1093/clinids/6.Supplement_2.S424|pmid=6740085|doi-access=free}}</ref> wey dem reduce de number of cases reported each year from an estimated 350,000 insyd 1988 to 33 insyd 2018.<ref name="gwp2013">{{cite web|url=http://polioeradication.org/wp-content/uploads/2019/02/global-wild-poliovirus-2013-2018-20190201.pdf|title=Global Wild Poliovirus 2014–2019|access-date=3 February 2019|archive-date=3 February 2019|archive-url=https://web.archive.org/web/20190203085212/http://polioeradication.org/wp-content/uploads/2019/02/global-wild-poliovirus-2013-2018-20190201.pdf|url-status=live}}</ref><ref>{{Cite web|url=https://www.who.int/features/qa/07/en/|title=Does polio still exist? Is it curable?|website=[[World Health Organization]] (WHO)|access-date=21 May 2018|archive-date=29 May 2018|archive-url=https://web.archive.org/web/20180529121019/http://www.who.int/features/qa/07/en/|url-status=live}}</ref> == References == [[Category:Translated from MDWiki]] cd12h0swhtq71kbotoc7foeciv1ndbz 98106 98105 2026-05-15T11:52:56Z DaSupremo 9 Improve article 98106 wikitext text/x-wiki {{Databox}} '''Polio vaccine''' be a vaccine dem use to prevent poliomyelitis (polio).<ref name="WHO20162">{{cite journal |date=2016 |title=Polio vaccines: WHO position paper – March, 2016 |journal=Weekly Epidemiological Record |volume=91 |issue=12 |pages=145–68 |hdl=10665/254399 |pmid=27039410 |hdl-access=free}}</ref><ref name=WHO2022>{{cite journal | title = Polio vaccines: WHO position paper – June 2022 | journal = Weekly Epidemiological Record | volume = 97 | issue = 25 | pages = 277–300 | date = 2022 | hdl=10665/357168 | hdl-access = free}}</ref> Two types be used: an inactivated poliovirus wey be given by injection (IPV) den a weakened poliovirus wey be given by mouth (OPV).<ref name="WHO20162" /> De World Health Organization (WHO) dey recommend all kiddies be fully vaccinated against polio.<ref name="WHO20162" /> De two vaccines eliminate polio from chaw of de world,<ref name="Aylward_2006">{{cite journal|vauthors=Aylward RB|year=2006|title=Eradicating polio: today's challenges and tomorrow's legacy|journal=Annals of Tropical Medicine and Parasitology|volume=100|issue=5–6|pages=401–413|doi=10.1179/136485906X97354|pmid=16899145|s2cid=25327986}}</ref><ref>{{cite journal|vauthors=Schonberger LB, Kaplan J, Kim-Farley R, Moore M, Eddins DL, Hatch M|year=1984|title=Control of paralytic poliomyelitis in the United States|journal=Reviews of Infectious Diseases|volume=6 | issue = Suppl 2|pages=S424–S426|doi=10.1093/clinids/6.Supplement_2.S424|pmid=6740085|doi-access=free}}</ref> wey dem reduce de number of cases reported each year from an estimated 350,000 insyd 1988 to 33 insyd 2018.<ref name="gwp2013">{{cite web|url=http://polioeradication.org/wp-content/uploads/2019/02/global-wild-poliovirus-2013-2018-20190201.pdf|title=Global Wild Poliovirus 2014–2019|access-date=3 February 2019|archive-date=3 February 2019|archive-url=https://web.archive.org/web/20190203085212/http://polioeradication.org/wp-content/uploads/2019/02/global-wild-poliovirus-2013-2018-20190201.pdf|url-status=live}}</ref><ref>{{Cite web|url=https://www.who.int/features/qa/07/en/|title=Does polio still exist? Is it curable?|website=[[World Health Organization]] (WHO)|access-date=21 May 2018|archive-date=29 May 2018|archive-url=https://web.archive.org/web/20180529121019/http://www.who.int/features/qa/07/en/|url-status=live}}</ref> De inactivated polio vaccines be very safe.<ref name=WHO2016/> Mild redness anaa pain fi occur at de site of injection.<ref name=WHO2016/> Oral polio vaccines dey cause about three cases of vaccine-associated paralytic poliomyelitis per million doses given.<ref name=WHO2016/> Dis dey compare plus 5,000 cases per million wey be paralysed dey follow a polio infection.<ref name="WHO2017Fs114">{{Cite web|url=https://www.who.int/mediacentre/factsheets/fs114/en/|title=Poliomyelitis|website=[[World Health Organization]] (WHO)|archive-url=https://web.archive.org/web/20170418105535/http://www.who.int/mediacentre/factsheets/fs114/en/|archive-date=18 April 2017|url-status = live|access-date=25 April 2017}}</ref> Both types of vaccine generally be safe to give during [[pregnancy]] den insyd those wey get [[HIV/AIDS]], buh be otherwise well.<ref name=WHO2016>{{cite journal | title = Polio vaccines: WHO position paper – March, 2016 | journal = Weekly Epidemiological Record | volume = 91 | issue = 12 | pages = 145–68 | date = 2016 | pmid = 27039410 | hdl=10665/254399 | hdl-access = free }}</ref> However, de emergence of circulating vaccine-derived poliovirus (cVDPV), a form of de vaccine virus wey be reverted to causing poliomyelitis, lead to de development of novel oral polio vaccine type 2 (nOPV2), wich dey aim to make de vaccine safer den thus stop further outbreaks of cVDPV.<ref name="GPEI-nOPV2">{{Cite web|title=GPEI-nOPV2|url=https://polioeradication.org/nopv2/|access-date=1 August 2021|archive-date=27 July 2021|archive-url=https://web.archive.org/web/20210727211943/https://polioeradication.org/nopv2/|url-status=live}}</ref> == References == [[Category:Translated from MDWiki]] <references /> == External links == n6bpforqidk0euagelgk97evbnc47i1 0 26871 98092 2026-05-14T18:38:35Z DaSupremo 9 Created by translating the page [[:mdwiki:Special:Redirect/revision/1458634|Delirium tremens]] to:gpe #mdwikicx 98092 wikitext text/x-wiki [[Category:Translated from MDWiki]] r0gf7axtnvt68k0p85plnlehx64o08u 98093 98092 2026-05-14T18:48:50Z DaSupremo 9 Improve article 98093 wikitext text/x-wiki {{Databox}} '''Delirium tremens''' ('''DTs'''; <abbr>lit.</abbr> 'mental disturbance with shaking') be a [[Delirium|rapid onset of confusion]] wey withdrawal from alcohol cause.<ref name="NEJM20142">{{cite journal |last1=Schuckit |first1=MA |date=November 27, 2014 |title=Recognition and management of withdrawal delirium (delirium tremens). |url=http://www.escholarship.org/uc/item/08b9z9th |journal=The New England Journal of Medicine |volume=371 |issue=22 |pages=2109–13 |doi=10.1056/NEJMra1407298 |pmid=25427113 |s2cid=205116954}}</ref> DT typically dey occur 48–72 hours after de last use of alcohol den symptoms dey last 1–8 days.<ref name="NEJM20142" /><ref name=":22">{{Cite journal |last1=Kaye |first1=Alan D |last2=Staser |first2=Amanda N |last3=Mccollins |first3=Tiombee S |last4=Zheng |first4=Jackson |last5=Berry |first5=Fouad A |last6=Burroughs |first6=Caroline R |last7=Heisler |first7=Michael |last8=Mouhaffel |first8=Aya |last9=Ahmadzadeh |first9=Shahab |last10=Kaye |first10=Adam M |last11=Shekoohi |first11=Sahar |last12=Varrassi |first12=Giustino |date=April 4, 2024 |title=Delirium Tremens: A Review of Clinical Studies |journal=Cureus |language=en |volume=16 |issue=4 |doi=10.7759/cureus.57601 |issn=2168-8184 |pmc=11069634 |pmid=38707114 |doi-access=free |article-number=e57601}}</ref> Typical symptoms dey include nightmares, confusion, disorientation, heavy sweating, elevated heart rate, den elevated blood pressure.<ref name=":22" /><ref name=Healy2008>{{cite book |first=David |last=Healy |title=Psychiatric Drugs Explained |url=https://books.google.com/books?id=ikTJViYMPIEC&pg=PA237 |date=December 3, 2008 |publisher=Elsevier Health Sciences |isbn=978-0-7020-2997-4 |page=237 |url-status=live |archive-url=https://web.archive.org/web/20170908181445/https://books.google.com/books?id=ikTJViYMPIEC&pg=PA237 |archive-date=September 8, 2017 }}</ref> Visual, auditory, den tactile hallucinations sanso be common.<ref name="NEJM20142" /> DT fi be fatal especially widout treatment. Occasionally, a very high body temperature anaa seizures (dem colloquially know as "rum fits")<ref>{{cite web |title=rum fits |url=https://medical-dictionary.thefreedictionary.com/rum+fits |website=Medical dictionary |publisher=Farlex, Inc. |access-date=November 22, 2022}}</ref><ref>{{cite journal |last1=Rhinehart |first1=John W. |title=Factors determining "rum fits" |journal=American Journal of Psychiatry |date=1961 |volume=118 |issue=3 |pages=251–252 |doi=10.1176/ajp.118.3.251 |pmid=13741146 |url=https://ajp.psychiatryonline.org/doi/10.1176/ajp.118.3.251 |url-access=subscription |access-date=February 1, 2023 |language=en |issn=0002-953X}}</ref> fi result in death.<ref name="NEJM20142" /> Oda causes of death dey include respiratory failure den cardiac arrhythmias.<ref name="NEJM20142" /> == References == [[Category:Translated from MDWiki]] <references /> == External links == 2557wv5rm0kvuxi1aonlqaul5of2dja 98094 98093 2026-05-14T18:55:39Z DaSupremo 9 Improve article 98094 wikitext text/x-wiki {{Databox}} '''Delirium tremens''' ('''DTs'''; <abbr>lit.</abbr> 'mental disturbance with shaking') be a [[Delirium|rapid onset of confusion]] wey withdrawal from alcohol cause.<ref name="NEJM20142">{{cite journal |last1=Schuckit |first1=MA |date=November 27, 2014 |title=Recognition and management of withdrawal delirium (delirium tremens). |url=http://www.escholarship.org/uc/item/08b9z9th |journal=The New England Journal of Medicine |volume=371 |issue=22 |pages=2109–13 |doi=10.1056/NEJMra1407298 |pmid=25427113 |s2cid=205116954}}</ref> DT typically dey occur 48–72 hours after de last use of alcohol den symptoms dey last 1–8 days.<ref name="NEJM20142" /><ref name=":22">{{Cite journal |last1=Kaye |first1=Alan D |last2=Staser |first2=Amanda N |last3=Mccollins |first3=Tiombee S |last4=Zheng |first4=Jackson |last5=Berry |first5=Fouad A |last6=Burroughs |first6=Caroline R |last7=Heisler |first7=Michael |last8=Mouhaffel |first8=Aya |last9=Ahmadzadeh |first9=Shahab |last10=Kaye |first10=Adam M |last11=Shekoohi |first11=Sahar |last12=Varrassi |first12=Giustino |date=April 4, 2024 |title=Delirium Tremens: A Review of Clinical Studies |journal=Cureus |language=en |volume=16 |issue=4 |doi=10.7759/cureus.57601 |issn=2168-8184 |pmc=11069634 |pmid=38707114 |doi-access=free |article-number=e57601}}</ref> Typical symptoms dey include nightmares, confusion, disorientation, heavy sweating, elevated heart rate, den elevated blood pressure.<ref name=":22" /><ref name=Healy2008>{{cite book |first=David |last=Healy |title=Psychiatric Drugs Explained |url=https://books.google.com/books?id=ikTJViYMPIEC&pg=PA237 |date=December 3, 2008 |publisher=Elsevier Health Sciences |isbn=978-0-7020-2997-4 |page=237 |url-status=live |archive-url=https://web.archive.org/web/20170908181445/https://books.google.com/books?id=ikTJViYMPIEC&pg=PA237 |archive-date=September 8, 2017 }}</ref> Visual, auditory, den tactile hallucinations sanso be common.<ref name="NEJM20142" /> DT fi be fatal especially widout treatment. Occasionally, a very high body temperature anaa seizures (dem colloquially know as "rum fits")<ref>{{cite web |title=rum fits |url=https://medical-dictionary.thefreedictionary.com/rum+fits |website=Medical dictionary |publisher=Farlex, Inc. |access-date=November 22, 2022}}</ref><ref>{{cite journal |last1=Rhinehart |first1=John W. |title=Factors determining "rum fits" |journal=American Journal of Psychiatry |date=1961 |volume=118 |issue=3 |pages=251–252 |doi=10.1176/ajp.118.3.251 |pmid=13741146 |url=https://ajp.psychiatryonline.org/doi/10.1176/ajp.118.3.251 |url-access=subscription |access-date=February 1, 2023 |language=en |issn=0002-953X}}</ref> fi result in death.<ref name="NEJM20142" /> Oda causes of death dey include respiratory failure den cardiac arrhythmias.<ref name="NEJM20142" /> Delirium tremens typically dey occur only insyd people plus a high intake of alcohol for prolonged periods of time, wey sharply reduced intake follow.<ref name="Stern20102">{{cite journal |last1=Stern |first1=TA |last2=Gross |first2=AF |last3=Stern |first3=TW |last4=Nejad |first4=SH |last5=Maldonado |first5=JR |date=2010 |title=Current approaches to the recognition and treatment of alcohol withdrawal and delirium tremens: "old wine in new bottles" or "new wine in old bottles" |journal=Primary Care Companion to the Journal of Clinical Psychiatry |volume=12 |issue=3 |doi=10.4088/PCC.10r00991ecr |pmc=2947546 |pmid=20944765}}</ref> A similar syndrome fi occur plus benzodiazepine den barbiturate withdrawal, however de term delirium tremens be reserved for alcohol withdrawal. Insyd a person plus delirium tremens, e be important to rule out oda associated problems such as electrolyte abnormalities, [[pancreatitis]], den alcoholic hepatitis.<ref name="NEJM20142" /> == References == [[Category:Translated from MDWiki]] <references /> == External links == 62a4gu3ooe6n1thf2kf0pjpnxj6pg5k 98095 98094 2026-05-14T19:12:28Z DaSupremo 9 Improve article 98095 wikitext text/x-wiki {{Databox}} '''Delirium tremens''' ('''DTs'''; <abbr>lit.</abbr> 'mental disturbance with shaking') be a [[Delirium|rapid onset of confusion]] wey withdrawal from alcohol cause.<ref name="NEJM20142">{{cite journal |last1=Schuckit |first1=MA |date=November 27, 2014 |title=Recognition and management of withdrawal delirium (delirium tremens). |url=http://www.escholarship.org/uc/item/08b9z9th |journal=The New England Journal of Medicine |volume=371 |issue=22 |pages=2109–13 |doi=10.1056/NEJMra1407298 |pmid=25427113 |s2cid=205116954}}</ref> DT typically dey occur 48–72 hours after de last use of alcohol den symptoms dey last 1–8 days.<ref name="NEJM20142" /><ref name=":22">{{Cite journal |last1=Kaye |first1=Alan D |last2=Staser |first2=Amanda N |last3=Mccollins |first3=Tiombee S |last4=Zheng |first4=Jackson |last5=Berry |first5=Fouad A |last6=Burroughs |first6=Caroline R |last7=Heisler |first7=Michael |last8=Mouhaffel |first8=Aya |last9=Ahmadzadeh |first9=Shahab |last10=Kaye |first10=Adam M |last11=Shekoohi |first11=Sahar |last12=Varrassi |first12=Giustino |date=April 4, 2024 |title=Delirium Tremens: A Review of Clinical Studies |journal=Cureus |language=en |volume=16 |issue=4 |doi=10.7759/cureus.57601 |issn=2168-8184 |pmc=11069634 |pmid=38707114 |doi-access=free |article-number=e57601}}</ref> Typical symptoms dey include nightmares, confusion, disorientation, heavy sweating, elevated heart rate, den elevated blood pressure.<ref name=":22" /><ref name=Healy2008>{{cite book |first=David |last=Healy |title=Psychiatric Drugs Explained |url=https://books.google.com/books?id=ikTJViYMPIEC&pg=PA237 |date=December 3, 2008 |publisher=Elsevier Health Sciences |isbn=978-0-7020-2997-4 |page=237 |url-status=live |archive-url=https://web.archive.org/web/20170908181445/https://books.google.com/books?id=ikTJViYMPIEC&pg=PA237 |archive-date=September 8, 2017 }}</ref> Visual, auditory, den tactile hallucinations sanso be common.<ref name="NEJM20142" /> DT fi be fatal especially widout treatment. Occasionally, a very high body temperature anaa seizures (dem colloquially know as "rum fits")<ref>{{cite web |title=rum fits |url=https://medical-dictionary.thefreedictionary.com/rum+fits |website=Medical dictionary |publisher=Farlex, Inc. |access-date=November 22, 2022}}</ref><ref>{{cite journal |last1=Rhinehart |first1=John W. |title=Factors determining "rum fits" |journal=American Journal of Psychiatry |date=1961 |volume=118 |issue=3 |pages=251–252 |doi=10.1176/ajp.118.3.251 |pmid=13741146 |url=https://ajp.psychiatryonline.org/doi/10.1176/ajp.118.3.251 |url-access=subscription |access-date=February 1, 2023 |language=en |issn=0002-953X}}</ref> fi result in death.<ref name="NEJM20142" /> Oda causes of death dey include respiratory failure den cardiac arrhythmias.<ref name="NEJM20142" /> Delirium tremens typically dey occur only insyd people plus a high intake of alcohol for prolonged periods of time, wey sharply reduced intake follow.<ref name="Stern20102">{{cite journal |last1=Stern |first1=TA |last2=Gross |first2=AF |last3=Stern |first3=TW |last4=Nejad |first4=SH |last5=Maldonado |first5=JR |date=2010 |title=Current approaches to the recognition and treatment of alcohol withdrawal and delirium tremens: "old wine in new bottles" or "new wine in old bottles" |journal=Primary Care Companion to the Journal of Clinical Psychiatry |volume=12 |issue=3 |doi=10.4088/PCC.10r00991ecr |pmc=2947546 |pmid=20944765}}</ref> A similar syndrome fi occur plus benzodiazepine den barbiturate withdrawal, however de term delirium tremens be reserved for alcohol withdrawal. Insyd a person plus delirium tremens, e be important to rule out oda associated problems such as electrolyte abnormalities, [[pancreatitis]], den alcoholic hepatitis.<ref name="NEJM20142" /> Prevention be by treating withdrawal symptoms using similarly acting compounds to taper off de use of de precipitating substance insyd a controlled fashion.<ref name="NEJM20142" /> If delirium tremens dey occur, aggressive treatment plus benzodiazepines dey improve outcomes.<ref name="NEJM20142" /> Treatment insyd a quiet intensive care unit plus sufficient light often be recommended to re-orient de patient.<ref name="NEJM20142" /> Benzodiazepines be de medication of choice plus short acting compounds wey dey include lorazepam den oxazepam commonly be used, wich bypass de liver.<ref name="Stern20102" /> Dese medications typically be given in response to de patient ein symptoms, rather dan at regular intervals.<ref name=":32">{{Cite journal |last=Haber |first=Paul S. |date=January 16, 2025 |editor-last=Ropper |editor-first=Allan H. |title=Identification and Treatment of Alcohol Use Disorder |url=http://www.nejm.org/doi/10.1056/NEJMra2306511 |journal=New England Journal of Medicine |language=en |volume=392 |issue=3 |pages=258–266 |doi=10.1056/NEJMra2306511 |issn=0028-4793 |pmid=39813644 |url-access=subscription}}</ref> Nonbenzodiazepines be often used as adjuncts to manage de sleep disturbance dem associate plus condition. De antipsychotic haloperidol sanso fi be used<ref name="NEJM20142" /> in order to combat de overactivity den possible excitotoxicity wey de withdrawal from a GABA-ergic substance cause. Antipsychotics, however, no be used alone as dem fi increase de risk of seizure.<ref name=":42">{{Cite report |url=https://downloads.asam.org/sitefinity-production-blobs/docs/default-source/quality-science/the_asam_clinical_practice_guideline_on_alcohol-1.pdf?sfvrsn=ba255c2_0 |title=Clinical Practice Guideline on Alcohol Withdrawal Management |last1=Alvanzo |first1=Anika |last2=Kleinschmidt |first2=Kurt |last3=Kmiec |first3=Julie A. |date=23 January 2020 |publisher=American Society of Addiction Medicine |display-authors=et al}}</ref> Thiamine (vitamin B₁) be recommended to be given intramuscularly,<ref name="NEJM20142" /> secof long-term high alcohol intake den de associated nutritional deficit dey lead to a thiamine deficiency, wich sam times no fi be rectified by supplement pills alone. == References == <references /> == External links == [[Category:Translated from MDWiki]] qc5riwpmr2j3ehpbuqo6ty4iprt5zyn 98096 98095 2026-05-14T19:15:29Z DaSupremo 9 Improve article 98096 wikitext text/x-wiki {{Databox}} '''Delirium tremens''' ('''DTs'''; <abbr>lit.</abbr> 'mental disturbance with shaking') be a [[Delirium|rapid onset of confusion]] wey withdrawal from alcohol cause.<ref name="NEJM20142">{{cite journal |last1=Schuckit |first1=MA |date=November 27, 2014 |title=Recognition and management of withdrawal delirium (delirium tremens). |url=http://www.escholarship.org/uc/item/08b9z9th |journal=The New England Journal of Medicine |volume=371 |issue=22 |pages=2109–13 |doi=10.1056/NEJMra1407298 |pmid=25427113 |s2cid=205116954}}</ref> DT typically dey occur 48–72 hours after de last use of alcohol den symptoms dey last 1–8 days.<ref name="NEJM20142" /><ref name=":22">{{Cite journal |last1=Kaye |first1=Alan D |last2=Staser |first2=Amanda N |last3=Mccollins |first3=Tiombee S |last4=Zheng |first4=Jackson |last5=Berry |first5=Fouad A |last6=Burroughs |first6=Caroline R |last7=Heisler |first7=Michael |last8=Mouhaffel |first8=Aya |last9=Ahmadzadeh |first9=Shahab |last10=Kaye |first10=Adam M |last11=Shekoohi |first11=Sahar |last12=Varrassi |first12=Giustino |date=April 4, 2024 |title=Delirium Tremens: A Review of Clinical Studies |journal=Cureus |language=en |volume=16 |issue=4 |doi=10.7759/cureus.57601 |issn=2168-8184 |pmc=11069634 |pmid=38707114 |doi-access=free |article-number=e57601}}</ref> Typical symptoms dey include nightmares, confusion, disorientation, heavy sweating, elevated heart rate, den elevated blood pressure.<ref name=":22" /><ref name=Healy2008>{{cite book |first=David |last=Healy |title=Psychiatric Drugs Explained |url=https://books.google.com/books?id=ikTJViYMPIEC&pg=PA237 |date=December 3, 2008 |publisher=Elsevier Health Sciences |isbn=978-0-7020-2997-4 |page=237 |url-status=live |archive-url=https://web.archive.org/web/20170908181445/https://books.google.com/books?id=ikTJViYMPIEC&pg=PA237 |archive-date=September 8, 2017 }}</ref> Visual, auditory, den tactile hallucinations sanso be common.<ref name="NEJM20142" /> DT fi be fatal especially widout treatment. Occasionally, a very high body temperature anaa seizures (dem colloquially know as "rum fits")<ref>{{cite web |title=rum fits |url=https://medical-dictionary.thefreedictionary.com/rum+fits |website=Medical dictionary |publisher=Farlex, Inc. |access-date=November 22, 2022}}</ref><ref>{{cite journal |last1=Rhinehart |first1=John W. |title=Factors determining "rum fits" |journal=American Journal of Psychiatry |date=1961 |volume=118 |issue=3 |pages=251–252 |doi=10.1176/ajp.118.3.251 |pmid=13741146 |url=https://ajp.psychiatryonline.org/doi/10.1176/ajp.118.3.251 |url-access=subscription |access-date=February 1, 2023 |language=en |issn=0002-953X}}</ref> fi result in death.<ref name="NEJM20142" /> Oda causes of death dey include respiratory failure den cardiac arrhythmias.<ref name="NEJM20142" /> Delirium tremens typically dey occur only insyd people plus a high intake of alcohol for prolonged periods of time, wey sharply reduced intake follow.<ref name="Stern20102">{{cite journal |last1=Stern |first1=TA |last2=Gross |first2=AF |last3=Stern |first3=TW |last4=Nejad |first4=SH |last5=Maldonado |first5=JR |date=2010 |title=Current approaches to the recognition and treatment of alcohol withdrawal and delirium tremens: "old wine in new bottles" or "new wine in old bottles" |journal=Primary Care Companion to the Journal of Clinical Psychiatry |volume=12 |issue=3 |doi=10.4088/PCC.10r00991ecr |pmc=2947546 |pmid=20944765}}</ref> A similar syndrome fi occur plus benzodiazepine den barbiturate withdrawal, however de term delirium tremens be reserved for alcohol withdrawal. Insyd a person plus delirium tremens, e be important to rule out oda associated problems such as electrolyte abnormalities, [[pancreatitis]], den alcoholic hepatitis.<ref name="NEJM20142" /> Prevention be by treating withdrawal symptoms using similarly acting compounds to taper off de use of de precipitating substance insyd a controlled fashion.<ref name="NEJM20142" /> If delirium tremens dey occur, aggressive treatment plus benzodiazepines dey improve outcomes.<ref name="NEJM20142" /> Treatment insyd a quiet intensive care unit plus sufficient light often be recommended to re-orient de patient.<ref name="NEJM20142" /> Benzodiazepines be de medication of choice plus short acting compounds wey dey include lorazepam den oxazepam commonly be used, wich bypass de liver.<ref name="Stern20102" /> Dese medications typically be given in response to de patient ein symptoms, rather dan at regular intervals.<ref name=":32">{{Cite journal |last=Haber |first=Paul S. |date=January 16, 2025 |editor-last=Ropper |editor-first=Allan H. |title=Identification and Treatment of Alcohol Use Disorder |url=http://www.nejm.org/doi/10.1056/NEJMra2306511 |journal=New England Journal of Medicine |language=en |volume=392 |issue=3 |pages=258–266 |doi=10.1056/NEJMra2306511 |issn=0028-4793 |pmid=39813644 |url-access=subscription}}</ref> Nonbenzodiazepines be often used as adjuncts to manage de sleep disturbance dem associate plus condition. De antipsychotic haloperidol sanso fi be used<ref name="NEJM20142" /> in order to combat de overactivity den possible excitotoxicity wey de withdrawal from a GABA-ergic substance cause. Antipsychotics, however, no be used alone as dem fi increase de risk of seizure.<ref name=":42">{{Cite report |url=https://downloads.asam.org/sitefinity-production-blobs/docs/default-source/quality-science/the_asam_clinical_practice_guideline_on_alcohol-1.pdf?sfvrsn=ba255c2_0 |title=Clinical Practice Guideline on Alcohol Withdrawal Management |last1=Alvanzo |first1=Anika |last2=Kleinschmidt |first2=Kurt |last3=Kmiec |first3=Julie A. |date=23 January 2020 |publisher=American Society of Addiction Medicine |display-authors=et al}}</ref> Thiamine (vitamin B₁) be recommended to be given intramuscularly,<ref name="NEJM20142" /> secof long-term high alcohol intake den de associated nutritional deficit dey lead to a thiamine deficiency, wich sam times no fi be rectified by supplement pills alone. Mortality widout treatment historically be between 15% den 40%.<ref name=Blom2010>{{cite book|last1=Blom|first1=Jan Dirk|title=A dictionary of hallucinations|date=2010|publisher=Springer|location=New York|isbn=978-1-4419-1223-7|page=136|edition=.|url=https://books.google.com/books?id=KJtQptBcZloC&pg=PA136|url-status=live|archive-url=https://web.archive.org/web/20160304224229/https://books.google.ca/books?id=KJtQptBcZloC&pg=PA136|archive-date=March 4, 2016}}</ref> Plus improvements insyd treatment over de years, currently death dey occur insyd about 1% to 4% of cases.<ref name=NEJM2014/> About half of people plus alcoholism go develop withdrawal symptoms upon reducing dema use.<ref name=NEJM2014/> Of dese, 3% to 5% dey develop DTs anaa dem get seizures.<ref name=NEJM2014>{{cite journal|last1=Schuckit|first1=MA|title=Recognition and management of withdrawal delirium (delirium tremens).|journal=The New England Journal of Medicine|date=November 27, 2014|volume=371|issue=22|pages=2109–13|pmid=25427113|doi=10.1056/NEJMra1407298|s2cid=205116954 |url=http://www.escholarship.org/uc/item/08b9z9th}}</ref> == References == <references /> == External links == [[Category:Translated from MDWiki]] 3wy3wde3039yoxo6hk43i78pqgpmhth 98097 98096 2026-05-14T19:18:04Z DaSupremo 9 Improve article 98097 wikitext text/x-wiki {{Databox}} '''Delirium tremens''' ('''DTs'''; <abbr>lit.</abbr> 'mental disturbance with shaking') be a [[Delirium|rapid onset of confusion]] wey withdrawal from alcohol cause.<ref name="NEJM20142">{{cite journal |last1=Schuckit |first1=MA |date=November 27, 2014 |title=Recognition and management of withdrawal delirium (delirium tremens). |url=http://www.escholarship.org/uc/item/08b9z9th |journal=The New England Journal of Medicine |volume=371 |issue=22 |pages=2109–13 |doi=10.1056/NEJMra1407298 |pmid=25427113 |s2cid=205116954}}</ref> DT typically dey occur 48–72 hours after de last use of alcohol den symptoms dey last 1–8 days.<ref name="NEJM20142" /><ref name=":22">{{Cite journal |last1=Kaye |first1=Alan D |last2=Staser |first2=Amanda N |last3=Mccollins |first3=Tiombee S |last4=Zheng |first4=Jackson |last5=Berry |first5=Fouad A |last6=Burroughs |first6=Caroline R |last7=Heisler |first7=Michael |last8=Mouhaffel |first8=Aya |last9=Ahmadzadeh |first9=Shahab |last10=Kaye |first10=Adam M |last11=Shekoohi |first11=Sahar |last12=Varrassi |first12=Giustino |date=April 4, 2024 |title=Delirium Tremens: A Review of Clinical Studies |journal=Cureus |language=en |volume=16 |issue=4 |doi=10.7759/cureus.57601 |issn=2168-8184 |pmc=11069634 |pmid=38707114 |doi-access=free |article-number=e57601}}</ref> Typical symptoms dey include nightmares, confusion, disorientation, heavy sweating, elevated heart rate, den elevated blood pressure.<ref name=":22" /><ref name=Healy2008>{{cite book |first=David |last=Healy |title=Psychiatric Drugs Explained |url=https://books.google.com/books?id=ikTJViYMPIEC&pg=PA237 |date=December 3, 2008 |publisher=Elsevier Health Sciences |isbn=978-0-7020-2997-4 |page=237 |url-status=live |archive-url=https://web.archive.org/web/20170908181445/https://books.google.com/books?id=ikTJViYMPIEC&pg=PA237 |archive-date=September 8, 2017 }}</ref> Visual, auditory, den tactile hallucinations sanso be common.<ref name="NEJM20142" /> DT fi be fatal especially widout treatment. Occasionally, a very high body temperature anaa seizures (dem colloquially know as "rum fits")<ref>{{cite web |title=rum fits |url=https://medical-dictionary.thefreedictionary.com/rum+fits |website=Medical dictionary |publisher=Farlex, Inc. |access-date=November 22, 2022}}</ref><ref>{{cite journal |last1=Rhinehart |first1=John W. |title=Factors determining "rum fits" |journal=American Journal of Psychiatry |date=1961 |volume=118 |issue=3 |pages=251–252 |doi=10.1176/ajp.118.3.251 |pmid=13741146 |url=https://ajp.psychiatryonline.org/doi/10.1176/ajp.118.3.251 |url-access=subscription |access-date=February 1, 2023 |language=en |issn=0002-953X}}</ref> fi result in death.<ref name="NEJM20142" /> Oda causes of death dey include respiratory failure den cardiac arrhythmias.<ref name="NEJM20142" /> Delirium tremens typically dey occur only insyd people plus a high intake of alcohol for prolonged periods of time, wey sharply reduced intake follow.<ref name="Stern20102">{{cite journal |last1=Stern |first1=TA |last2=Gross |first2=AF |last3=Stern |first3=TW |last4=Nejad |first4=SH |last5=Maldonado |first5=JR |date=2010 |title=Current approaches to the recognition and treatment of alcohol withdrawal and delirium tremens: "old wine in new bottles" or "new wine in old bottles" |journal=Primary Care Companion to the Journal of Clinical Psychiatry |volume=12 |issue=3 |doi=10.4088/PCC.10r00991ecr |pmc=2947546 |pmid=20944765}}</ref> A similar syndrome fi occur plus benzodiazepine den barbiturate withdrawal, however de term delirium tremens be reserved for alcohol withdrawal. Insyd a person plus delirium tremens, e be important to rule out oda associated problems such as electrolyte abnormalities, [[pancreatitis]], den alcoholic hepatitis.<ref name="NEJM20142" /> Prevention be by treating withdrawal symptoms using similarly acting compounds to taper off de use of de precipitating substance insyd a controlled fashion.<ref name="NEJM20142" /> If delirium tremens dey occur, aggressive treatment plus benzodiazepines dey improve outcomes.<ref name="NEJM20142" /> Treatment insyd a quiet intensive care unit plus sufficient light often be recommended to re-orient de patient.<ref name="NEJM20142" /> Benzodiazepines be de medication of choice plus short acting compounds wey dey include lorazepam den oxazepam commonly be used, wich bypass de liver.<ref name="Stern20102" /> Dese medications typically be given in response to de patient ein symptoms, rather dan at regular intervals.<ref name=":32">{{Cite journal |last=Haber |first=Paul S. |date=January 16, 2025 |editor-last=Ropper |editor-first=Allan H. |title=Identification and Treatment of Alcohol Use Disorder |url=http://www.nejm.org/doi/10.1056/NEJMra2306511 |journal=New England Journal of Medicine |language=en |volume=392 |issue=3 |pages=258–266 |doi=10.1056/NEJMra2306511 |issn=0028-4793 |pmid=39813644 |url-access=subscription}}</ref> Nonbenzodiazepines be often used as adjuncts to manage de sleep disturbance dem associate plus condition. De antipsychotic haloperidol sanso fi be used<ref name="NEJM20142" /> in order to combat de overactivity den possible excitotoxicity wey de withdrawal from a GABA-ergic substance cause. Antipsychotics, however, no be used alone as dem fi increase de risk of seizure.<ref name=":42">{{Cite report |url=https://downloads.asam.org/sitefinity-production-blobs/docs/default-source/quality-science/the_asam_clinical_practice_guideline_on_alcohol-1.pdf?sfvrsn=ba255c2_0 |title=Clinical Practice Guideline on Alcohol Withdrawal Management |last1=Alvanzo |first1=Anika |last2=Kleinschmidt |first2=Kurt |last3=Kmiec |first3=Julie A. |date=23 January 2020 |publisher=American Society of Addiction Medicine |display-authors=et al}}</ref> Thiamine (vitamin B₁) be recommended to be given intramuscularly,<ref name="NEJM20142" /> secof long-term high alcohol intake den de associated nutritional deficit dey lead to a thiamine deficiency, wich sam times no fi be rectified by supplement pills alone. Mortality widout treatment historically be between 15% den 40%.<ref name=Blom2010>{{cite book|last1=Blom|first1=Jan Dirk|title=A dictionary of hallucinations|date=2010|publisher=Springer|location=New York|isbn=978-1-4419-1223-7|page=136|edition=.|url=https://books.google.com/books?id=KJtQptBcZloC&pg=PA136|url-status=live|archive-url=https://web.archive.org/web/20160304224229/https://books.google.ca/books?id=KJtQptBcZloC&pg=PA136|archive-date=March 4, 2016}}</ref> Plus improvements insyd treatment over de years, currently death dey occur insyd about 1% to 4% of cases.<ref name=NEJM2014/> About half of people plus alcoholism go develop withdrawal symptoms upon reducing dema use.<ref name=NEJM2014/> Of dese, 3% to 5% dey develop DTs anaa dem get seizures.<ref name=NEJM2014>{{cite journal|last1=Schuckit|first1=MA|title=Recognition and management of withdrawal delirium (delirium tremens).|journal=The New England Journal of Medicine|date=November 27, 2014|volume=371|issue=22|pages=2109–13|pmid=25427113|doi=10.1056/NEJMra1407298|s2cid=205116954 |url=http://www.escholarship.org/uc/item/08b9z9th}}</ref> De name delirium tremens first be used insyd 1813; however, de symptoms be well described since de 1700s.<ref name=Stern2010>{{cite journal|last1=Stern|first1=TA|last2=Gross|first2=AF|last3=Stern|first3=TW|last4=Nejad|first4=SH|last5=Maldonado|first5=JR|title=Current approaches to the recognition and treatment of alcohol withdrawal and delirium tremens: "old wine in new bottles" or "new wine in old bottles"|journal=Primary Care Companion to the Journal of Clinical Psychiatry|date=2010|volume=12|issue=3|pmid=20944765|doi=10.4088/PCC.10r00991ecr|pmc=2947546}}</ref> De word "delirium" be Latin for "going off de furrow", a plowing metaphor give disordered thinking.<ref name=Blom2010/> E sanso be called de shaking frenzy den Saunders-Sutton syndrome.<ref name=Blom2010/> Der be numerous nickies give de condition, wey dey include "de DTs" den "seeing pink elephants". == References == <references /> == External links == [[Category:Translated from MDWiki]] ir63mkbo8d9cwxqt9od285pzrtlz8nc 98098 98097 2026-05-14T19:19:54Z DaSupremo 9 Improve article 98098 wikitext text/x-wiki {{Databox}} '''Delirium tremens''' ('''DTs'''; <abbr>lit.</abbr> 'mental disturbance with shaking') be a [[Delirium|rapid onset of confusion]] wey withdrawal from alcohol cause.<ref name="NEJM20142">{{cite journal |last1=Schuckit |first1=MA |date=November 27, 2014 |title=Recognition and management of withdrawal delirium (delirium tremens). |url=http://www.escholarship.org/uc/item/08b9z9th |journal=The New England Journal of Medicine |volume=371 |issue=22 |pages=2109–13 |doi=10.1056/NEJMra1407298 |pmid=25427113 |s2cid=205116954}}</ref> DT typically dey occur 48–72 hours after de last use of alcohol den symptoms dey last 1–8 days.<ref name="NEJM20142" /><ref name=":22">{{Cite journal |last1=Kaye |first1=Alan D |last2=Staser |first2=Amanda N |last3=Mccollins |first3=Tiombee S |last4=Zheng |first4=Jackson |last5=Berry |first5=Fouad A |last6=Burroughs |first6=Caroline R |last7=Heisler |first7=Michael |last8=Mouhaffel |first8=Aya |last9=Ahmadzadeh |first9=Shahab |last10=Kaye |first10=Adam M |last11=Shekoohi |first11=Sahar |last12=Varrassi |first12=Giustino |date=April 4, 2024 |title=Delirium Tremens: A Review of Clinical Studies |journal=Cureus |language=en |volume=16 |issue=4 |doi=10.7759/cureus.57601 |issn=2168-8184 |pmc=11069634 |pmid=38707114 |doi-access=free |article-number=e57601}}</ref> Typical symptoms dey include nightmares, confusion, disorientation, heavy sweating, elevated heart rate, den elevated blood pressure.<ref name=":22" /><ref name=Healy2008>{{cite book |first=David |last=Healy |title=Psychiatric Drugs Explained |url=https://books.google.com/books?id=ikTJViYMPIEC&pg=PA237 |date=December 3, 2008 |publisher=Elsevier Health Sciences |isbn=978-0-7020-2997-4 |page=237 |url-status=live |archive-url=https://web.archive.org/web/20170908181445/https://books.google.com/books?id=ikTJViYMPIEC&pg=PA237 |archive-date=September 8, 2017 }}</ref> Visual, auditory, den tactile hallucinations sanso be common.<ref name="NEJM20142" /> DT fi be fatal especially widout treatment. Occasionally, a very high body temperature anaa seizures (dem colloquially know as "rum fits")<ref>{{cite web |title=rum fits |url=https://medical-dictionary.thefreedictionary.com/rum+fits |website=Medical dictionary |publisher=Farlex, Inc. |access-date=November 22, 2022}}</ref><ref>{{cite journal |last1=Rhinehart |first1=John W. |title=Factors determining "rum fits" |journal=American Journal of Psychiatry |date=1961 |volume=118 |issue=3 |pages=251–252 |doi=10.1176/ajp.118.3.251 |pmid=13741146 |url=https://ajp.psychiatryonline.org/doi/10.1176/ajp.118.3.251 |url-access=subscription |access-date=February 1, 2023 |language=en |issn=0002-953X}}</ref> fi result in death.<ref name="NEJM20142" /> Oda causes of death dey include respiratory failure den cardiac arrhythmias.<ref name="NEJM20142" /> Delirium tremens typically dey occur only insyd people plus a high intake of alcohol for prolonged periods of time, wey sharply reduced intake follow.<ref name="Stern20102">{{cite journal |last1=Stern |first1=TA |last2=Gross |first2=AF |last3=Stern |first3=TW |last4=Nejad |first4=SH |last5=Maldonado |first5=JR |date=2010 |title=Current approaches to the recognition and treatment of alcohol withdrawal and delirium tremens: "old wine in new bottles" or "new wine in old bottles" |journal=Primary Care Companion to the Journal of Clinical Psychiatry |volume=12 |issue=3 |doi=10.4088/PCC.10r00991ecr |pmc=2947546 |pmid=20944765}}</ref> A similar syndrome fi occur plus benzodiazepine den barbiturate withdrawal, however de term delirium tremens be reserved for alcohol withdrawal. Insyd a person plus delirium tremens, e be important to rule out oda associated problems such as electrolyte abnormalities, [[pancreatitis]], den alcoholic hepatitis.<ref name="NEJM20142" /> Prevention be by treating withdrawal symptoms using similarly acting compounds to taper off de use of de precipitating substance insyd a controlled fashion.<ref name="NEJM20142" /> If delirium tremens dey occur, aggressive treatment plus benzodiazepines dey improve outcomes.<ref name="NEJM20142" /> Treatment insyd a quiet intensive care unit plus sufficient light often be recommended to re-orient de patient.<ref name="NEJM20142" /> Benzodiazepines be de medication of choice plus short acting compounds wey dey include lorazepam den oxazepam commonly be used, wich bypass de liver.<ref name="Stern20102" /> Dese medications typically be given in response to de patient ein symptoms, rather dan at regular intervals.<ref name=":32">{{Cite journal |last=Haber |first=Paul S. |date=January 16, 2025 |editor-last=Ropper |editor-first=Allan H. |title=Identification and Treatment of Alcohol Use Disorder |url=http://www.nejm.org/doi/10.1056/NEJMra2306511 |journal=New England Journal of Medicine |language=en |volume=392 |issue=3 |pages=258–266 |doi=10.1056/NEJMra2306511 |issn=0028-4793 |pmid=39813644 |url-access=subscription}}</ref> Nonbenzodiazepines be often used as adjuncts to manage de sleep disturbance dem associate plus condition. De antipsychotic haloperidol sanso fi be used<ref name="NEJM20142" /> in order to combat de overactivity den possible excitotoxicity wey de withdrawal from a GABA-ergic substance cause. Antipsychotics, however, no be used alone as dem fi increase de risk of seizure.<ref name=":42">{{Cite report |url=https://downloads.asam.org/sitefinity-production-blobs/docs/default-source/quality-science/the_asam_clinical_practice_guideline_on_alcohol-1.pdf?sfvrsn=ba255c2_0 |title=Clinical Practice Guideline on Alcohol Withdrawal Management |last1=Alvanzo |first1=Anika |last2=Kleinschmidt |first2=Kurt |last3=Kmiec |first3=Julie A. |date=23 January 2020 |publisher=American Society of Addiction Medicine |display-authors=et al}}</ref> Thiamine (vitamin B₁) be recommended to be given intramuscularly,<ref name="NEJM20142" /> secof long-term high alcohol intake den de associated nutritional deficit dey lead to a thiamine deficiency, wich sam times no fi be rectified by supplement pills alone. Mortality widout treatment historically be between 15% den 40%.<ref name=Blom2010>{{cite book|last1=Blom|first1=Jan Dirk|title=A dictionary of hallucinations|date=2010|publisher=Springer|location=New York|isbn=978-1-4419-1223-7|page=136|edition=.|url=https://books.google.com/books?id=KJtQptBcZloC&pg=PA136|url-status=live|archive-url=https://web.archive.org/web/20160304224229/https://books.google.ca/books?id=KJtQptBcZloC&pg=PA136|archive-date=March 4, 2016}}</ref> Plus improvements insyd treatment over de years, currently death dey occur insyd about 1% to 4% of cases.<ref name=NEJM2014/> About half of people plus alcoholism go develop withdrawal symptoms upon reducing dema use.<ref name=NEJM2014/> Of dese, 3% to 5% dey develop DTs anaa dem get seizures.<ref name=NEJM2014>{{cite journal|last1=Schuckit|first1=MA|title=Recognition and management of withdrawal delirium (delirium tremens).|journal=The New England Journal of Medicine|date=November 27, 2014|volume=371|issue=22|pages=2109–13|pmid=25427113|doi=10.1056/NEJMra1407298|s2cid=205116954 |url=http://www.escholarship.org/uc/item/08b9z9th}}</ref> De name delirium tremens first be used insyd 1813; however, de symptoms be well described since de 1700s.<ref name=Stern2010>{{cite journal|last1=Stern|first1=TA|last2=Gross|first2=AF|last3=Stern|first3=TW|last4=Nejad|first4=SH|last5=Maldonado|first5=JR|title=Current approaches to the recognition and treatment of alcohol withdrawal and delirium tremens: "old wine in new bottles" or "new wine in old bottles"|journal=Primary Care Companion to the Journal of Clinical Psychiatry|date=2010|volume=12|issue=3|pmid=20944765|doi=10.4088/PCC.10r00991ecr|pmc=2947546}}</ref> De word "delirium" be Latin for "going off de furrow", a plowing metaphor give disordered thinking.<ref name=Blom2010/> E sanso be called de shaking frenzy den Saunders-Sutton syndrome.<ref name=Blom2010/> Der be numerous nickies give de condition, wey dey include "de DTs" den "seeing pink elephants". == References == <references /> == External links == {{Commons}} * [https://castlecraig.co.uk/blog/2021/01/27/why-does-alcohol-cause-the-shakes Why Does Alcohol Cause the Shakes?] | Alcohol Withdrawal Syndrome Tremors | Dr Peter MCcann MCC, MBBS | Castle Craig Hospital {{Authority control}} {{DEFAULTSORT:Delirium Tremens}} [[Category:Causes of death]] [[Category:Health effects of alcohol]] [[Category:Addiction psychiatry]] [[Category:Intensive care medicine]] [[Category:Neurological disorders]] [[Category:Latin medical words den phrases]] [[Category:Medical emergencies]] [[Category:Alcohol abuse]] [[Category:Disorders secof use of alcohol]] [[Category:Delirium]] [[Category:Translated from MDWiki]] qzv0e01zuslhztvj3y41rhi8roxb7hk 14 26872 98099 2026-05-14T19:20:22Z DaSupremo 9 Fresh category 98099 wikitext text/x-wiki phoiac9h4m842xq45sp7s6u21eteeq1 14 26873 98100 2026-05-14T20:09:24Z DaSupremo 9 Fresh category 98100 wikitext text/x-wiki phoiac9h4m842xq45sp7s6u21eteeq1 14 26874 98101 2026-05-14T20:09:36Z DaSupremo 9 Fresh category 98101 wikitext text/x-wiki phoiac9h4m842xq45sp7s6u21eteeq1